Blue Light Plus Exercise Restores Memory and Brain Rhythms in Alzheimer’s Mice
A one-week combination of ipRGC-sensitive blue light and exercise rescued memory deficits and restored pathological hippocampal rhythms in Alzheimer's model ...
Tag: Alzheimer’s disease
New AI Model Turns Short Amyloid PET Scans into Full Late-Phase Images
A new generative AI framework called MOVIE synthesizes late-phase amyloid PET images from one-minute early-phase scans, outperforming a UNet baseline ...
Exon-Skipping Splicing Changes Distinguish Alzheimer’s Disease from Progressive Supranuclear Palsy
A genomic study of temporal cortex tissue identifies hundreds of exon-skipping events that separate Alzheimer's disease from progressive supranuclear palsy, ...
CSF APOE4 protein levels track tau pathology better than HDL measures in Alzheimer’s
A study of 144 ADNI participants found that CSF APOE4 protein levels, not HDL particle concentrations, were associated with tau ...
Blood Test for Alzheimer’s Reshapes Dementia Diagnosis in Real-World Clinics
A real-world study of 1,368 patients across 24 centers shows plasma p-tau217 distributions vary by clinical category, age and kidney ...
Psychological factors shape dementia risk, new perspective argues
A Nature Mental Health perspective synthesizes evidence linking psychological risk factors such as loneliness and protective factors such as purpose ...
Green Tea and Soy Phytochemicals Show Neuroprotective Effects in Lab Models of Alzheimer’s Disease
A new in vitro study finds that epicatechin gallate from green tea and genistin from soybeans inhibit cholinesterases, reduce oxidative ...
Diabetes drugs show early brain signals but no proven benefit in Alzheimer’s, review finds
A systematic review of nine randomized studies finds exploratory biomarker and neuroimaging signals for GLP-1 receptor agonists and SGLT-2 inhibitors ...
Blood biomarker pTau217 fails to predict mortality or autonomy decline in older adults
A prospective eight-year follow-up found that plasma pTau217 levels suggesting amyloidosis were common in community-dwelling older adults but did not ...
TabNet brings interpretable attention to miRNA classification, but classical models still lead
A leakage-controlled benchmark of TabNet and eight baselines on cervical cancer and Alzheimer's disease miRNA datasets finds a shared accuracy ...
Retuning Synaptic Dynamics Restores Memory Signals in Alzheimer’s Model
A computational model of Alzheimer's disease shows that adjusting short-term synaptic facilitation time constants can restore memory engram selectivity and ...
Geneticists certify 108 high-confidence Alzheimer’s risk signals
A systematic adjudication framework applied to 29 genome-wide studies produced a catalog of 108 high-confidence genetic signals for Alzheimer's disease ...
Attention-Guided Distillation Boost Alzheimer’s Stage Identification Using MRI Scans
Researchers introduce an attention-guided cross-representation distillation framework that utilizes MRI scans to achieve high accuracy in identifying subtle stages of ...
Tau, Not Just Amyloid, May Drive the Fast Cognitive Hits of Sleep Loss, Researchers Argue
A new opinion article in Frontiers in Neurology argues that tau-related mechanisms, which respond rapidly to sleep loss, deserve far ...
Gut Microbiota Research on Cognitive Decline in Older Adults Maps a Rapidly Growing Field
A bibliometric analysis of 406 publications reveals China leading output, Alzheimer's disease dominating the research agenda, and multi-omics integration shaping ...
Chronic Neuropeptide S Treatment Restores Sleep and Cuts Amyloid Pathology in Alzheimer’s Mice
Chronic intracerebroventricular neuropeptide S treatment increased NREM sleep and reduced amyloid-related pathology in APP/PS1 Alzheimer's model mice, with BV2 cell ...
Quetiapine edges out rival antipsychotics in Alzheimer’s behavioral symptoms, with far fewer movement side effects
A meta-analysis of 25 randomized controlled trials in Alzheimer's disease finds quetiapine associated with lower odds of treatment failure than ...
High-Salt Diet Impairs Memory in Aged Mice by Overwhelming Mitochondrial Cleanup
A two-month high-salt diet impaired learning and memory in aged male mice and increased amyloid-beta accumulation, activating a PINK1/Parkin mitophagy ...
Scoping Review Finds Gaps in Person-Centred Dementia Diagnosis
A scoping review of 23 publications finds that person-centred dementia diagnosis emphasizes assessment and relationships while leaving uncertainty, shared decisions, ...
Protein Maps Chart Antibodies Across Mouse Brain Tissue
A mouse-brain study generated maps of monoclonal antibodies and more than 6,000 proteins across tissue sections, demonstrating a preclinical method ...
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