BCG vaccine reduces tau pathology and improves memory in dementia-model mice
A controlled study of mice with tau pathology found that BCG vaccination reduced brain inflammation and tau deposition and improved ...
Tag: Alzheimer’s disease
Crossing the Blood–Brain Barrier Is No Longer the Hard Part, Researchers Argue
A PLoS Biology perspective argues that the real challenge in treating neurodegenerative disease is no longer crossing the blood–brain barrier, ...
New Alzheimer’s Microsimulation Model Translates Slowed Cognitive Decline into Years of Independence
Researchers built a microsimulation model from biomarker-confirmed Alzheimer's disease patients showing that a 30% slowing of cognitive decline extends time ...
NIH-funded project develops unified AI platform for brain imaging analysis
A Lehigh-led team received a four-year, $2.8 million NIH grant to develop UniBrain, a unified AI platform for streamlining brain-imaging ...
Genome re-identification attack works in theory but falters in practice
A new probabilistic study shows that re-identifying anonymized genomes from predicted traits achieves high precision only under unrealistically favorable assumptions, ...
Alzheimer’s Mouse Model Shows Sex-Specific Muscle Fatigue Changes Before Cognitive Decline
In a humanized amyloid beta knock-in mouse model of sporadic Alzheimer's disease, 8-month-old males show faster muscle fatigue while females ...
Amyloid biomarkers track sleep spindle changes in cognitively healthy older adults
In cognitively unimpaired adults aged 55 to 75, plasma amyloid-beta levels were consistently associated with shorter and less dense frontal ...
Papaya Extracts Show Neuroprotective Signals in Preclinical Models, Review Finds
A new comprehensive review finds that papaya leaf, seed, fruit, and fermented preparations display antioxidant, anti-inflammatory, and neuromodulatory effects in ...
Tablet-based augmented reality test spots mild cognitive impairment in under 15 minutes
A cross-sectional study of 638 older adults across three countries found that a self-administered tablet-based assessment combining motoric, augmented reality, ...
Experimental drug rejuvenates aged rat livers, halving amyloid beta and LDL
In aged rats, the experimental drug cinaciguat restored aging liver sieve cells, cutting blood amyloid beta in half and lowering ...
Super-resolution GAN and swarm-optimized transfer learning sharpen Alzheimer’s MRI classification
A new deep learning framework that pairs super-resolution image enhancement with swarm-optimized transfer learning classified Alzheimer's disease stages from MRI ...
Gut bacterium Faecalibacterium prausnitzii emerges as candidate probiotic for neurological disorders
A new review consolidates evidence that the butyrate-producing gut bacterium Faecalibacterium prausnitzii is depleted across several neurological disorders and shows ...
Loneliness linked to smaller brain memory regions when Alzheimer’s biomarker is elevated
A large IGNITE study of cognitively unimpaired older adults found that loneliness was associated with smaller CA3 and entorhinal cortex ...
Rare tau gene variant reshapes brain cell transcriptomes in Alzheimer’s and PSP
Single-nucleus RNA sequencing of postmortem brains reveals that carriers of the rare MAPT A152T variant show distinct cell type-specific gene-expression ...
Fibril-selective nanantibody reduces amyloid injury signals in human brain models
A fibril-selective, Fc-free nanantibody bound Alzheimer’s-associated amyloid assemblies and reduced injury signals in human neurons and forebrain organoids, while remaining ...
Donepezil-linked network gains fade as cognition and hippocampus decline
A 36-month retrospective study associated donepezil with early, short-lived brain-network gains but continued cognitive decline and left-hippocampal atrophy in Alzheimer’s-related ...
Two-stage blood algorithm reduces amyloid PET use in validated Alzheimer’s triage study
An externally validated two-stage blood-biomarker algorithm reduced the need for amyloid PET by resolving more uncertain p-Tau217 results while retaining ...
Real-world lecanemab data show ARIA risks and limited cognitive evidence
A meta-analysis of 37 real-world lecanemab studies found ARIA in 15.1% of cases, with higher rates among APOE ε4 homozygotes ...
Shared Pathways Link Autism and Alzheimer’s, but Causality Remains Unproven
A 2026 review identifies shared pathways involving synapses, immunity, metabolism, epigenetics and waste clearance in autism and Alzheimer’s disease, while ...
Automated p-tau217 test identifies amyloid pathology in Taiwanese memory clinic
An automated Roche p-tau217 blood test showed high accuracy for identifying brain amyloid pathology and placed 88.1% of a Taiwanese ...
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