Biology
Mined diagnostic sequences reveal ordered illness paths tied to suicide death
Temporal sequence mining of linked claims and mortality data from 3.6 million Maryland residents identified 1,816 ordered diagnostic trajectories significantly...
Extracellular vesicles emerge as dual players and tools in cancer immunotherapy
A new review describes how tumor-derived exosomes suppress immunity while immune-cell-derived vesicles boost antitumor responses, highlighting exosome-based vaccines and biomarkers.
HSP90B1 drives cardiomyocyte pyroptosis and inflammation after heart attack, mouse study finds
A new study links the ER chaperone HSP90B1 to cardiomyocyte pyroptosis, NF-κB/NLRP3 signaling, and M1-like macrophage polarization after myocardial infarction.
Saliva proteins may flag orthodontic root resorption, pilot study suggests
A pilot study reports that salivary Caspase-1 and Osteopontin are significantly elevated in orthodontic patients with radiographically confirmed root resorption,...
New karst-dwelling shrub Euonymus saxatilis described from Guangxi, China
A new Euonymus species from karst slopes in Guangxi, China, is distinguished from its closest relative by leaf, flower and...
Cancer cells ramp up transcription across the genome, review finds
A new review describes how global transcriptional upregulation, or hypertranscription, driven by oncogene-encoded transcription factors may contribute to chromosomal instability...
Bigger Rodents Eat a Wider Menu in Tanzania’s Mount Rungwe Forest
A study of four rodent species in Tanzania's Mount Rungwe Forest finds that larger-bodied rodents have broader dietary niches, with...
Passive eDNA samplers and coral genetic markers tested for reef monitoring in Hawaiʻi
A Hawaiʻi study compared passive and active environmental DNA sampling methods and coral genetic markers for community-based coral reef monitoring.
Kangaroo and wallaby facial artery map revealed in new anatomical study
A new anatomical study maps the external carotid artery branches in red kangaroos and red-necked wallabies, finding largely similar facial...
SARS-CoV-2 Spike Protein Competes with ENaC for Plasmin Cleavage, Driving Pulmonary Edema
A new study reports that the SARS-CoV-2 spike protein competitively inhibits plasmin-mediated cleavage of the epithelial sodium channel ENaC at...
Scientists Report First Chemical Probes That Block CDCA7’s DNA Recognition
Structure-guided screening has yielded two compounds that selectively interfere with CDCA7 binding to hemi-methylated DNA, partially recapitulating phenotypes of CDCA7...
Nuclear CK1α joins the WNT transcription machine to drive tumor-initiating cells
Nuclear L-insert-containing CK1α isoforms act as positive components of the β-catenin/TCF complex, while pharmacological CK1α activation with SSTC3 depletes WNT-driven...
Indian environmental mutagenesis conference links pollution, pesticides and DNA damage to human health
The 48th EMSI conference in Jamshedpur featured 141 deliberations linking environmental mutagens, microplastics and pesticides to human health and sustainable...
Egg chemicals guide a tiny wasp’s hunt for pest moth eggs
Female Telenomus remus wasps were attracted to eggs of three moth species, and seven egg-surface compounds elicited significant behavioral responses...
Mutated neutrophils may trigger immune self-attack in lupus patients
New research in Nature finds that 33 of 34 lupus patients carried neutrophils with RNA splicing mutations producing neoantigens that...
New Green-Flowered Legume Species Discovered in Guangxi Forests of China
A new shrubby legume species with green flowers and five stamens has been described from Guangxi, China, and assessed as...
Turnip-made magnesium nanoparticles dismantle drug-resistant bacterial biofilms in lab tests
A laboratory study reports that magnesium oxide nanoparticles synthesised with turnip leaf extract inhibited multidrug-resistant Gram-negative bacteria and reduced established...
Compact engineered Cas12m enables multiplexed CRISPR gene activation in mice
An engineered compact Cas12m variant enables multiplexed CRISPR gene activation from a single AAV vector in mouse models.
Salmonella’s SopB protein makes a key signalling lipid without host kinases
A new review explains how the bacterial effector SopB uses phosphatase, phosphotransferase and scaffolding activities to rewire host phosphoinositide signalling...
Tiny parasitoid wasps of China get their first complete identification key
A new taxonomic review documents seventeen Tetrastichus wasp species in China, reports three national records, and delivers the first complete...
POPULAR NEWS
-
Protein C Gene Variant Tied to Higher Venous Thrombosis Risk in Taiwanese Cohort
-
Multi-Material Topology Optimization Tool Integrates Complex Load Cases and Structural Analysis
-
Kidney-centered framework turns CKM risk scores into treatment priorities
-
Natural Fungal Control Suppresses Invasive Vampire Moth Across Türkiye’s Black Sea Region