Study Links Synovial Protein Misfolding to Osteoarthritis Inflammation
A new study in Arthritis Research & Therapy links protein misfolding in the synovium to the severity of osteoarthritis inflammation, ...
Tag: proteostasis
Quality Control at the ER Gateway: How Cells Police Protein Entry Before Translocation
A new review describes a multilayered quality control network that safeguards secretory and membrane proteins from targeting through translocation at ...
Two Enzymes Team Up to Drive Fat Cell Formation and Obesity
Researchers found that the enzymes USP25 and USP28 work together to stabilize key fat-forming transcription factors, and blocking both simultaneously ...
Millimeter-Wave Directed Energy Induces Severe Protein Degradation in Cultured Neural Cells
Exposure to 34.14 GHz millimeter-wave directed energy causes spatially graded neural cell injury characterized by cytoskeletal protein degradation, membrane permeabilization, ...
Dietary Vanadyl Sulfate Selectively Eliminates Senescent Cells and Extends Mouse Lifespan
Researchers have discovered that vanadyl sulfate acts as a selective senolytic agent by disrupting vulnerable protein-folding machinery in senescent cells, ...
Review Outlines Cardiovascular Impact and Treatment Frontiers in Protein Misfolding Diseases
A comprehensive review outlines how the failure of proteostasis drives cardiac and vascular injury in protein misfolding diseases while charting ...
Sleep loss after brain injury boosts early Alzheimer-like protein changes in mice
A new mouse study shows that traumatic brain injury alone triggers early Alzheimer-like protein variant buildup in wild-type animals, and ...
TBK1 clears aggregation-prone TDP-43 via an IFNβ-immunoproteasome pathway in ALS models
Researchers report that the ALS-linked kinase TBK1 clears aggregation-prone monomeric TDP-43 in neurons by inducing interferon-β and the immunoproteasome, an ...
Drug Repurposing Candidate Ebselen Boosts Mitochondrial Function Across Disease Models
A preclinical study reports that the organoselenium compound ebselen improved mitochondrial respiration, ATP production and exercise capacity in yeast, human ...
tRNA Fragments May Link Chronic Stress to Translation Failure in Alzheimer’s Disease
A new review proposes that tRNA-derived small RNAs link chronic cellular stress to maladaptive translational remodeling in Alzheimer's disease.
Liver Survival Protein USP18 Protects Cells From Proteotoxic Stress
A study in mice and liver cells finds that the USP18–STAT2 axis, activated by interferon priming, protects hepatocytes from proteasome-inhibitor-induced ...
Blocked protein cleanup reroutes toxic TDP-43 cargo through extracellular vesicles
In motor neuron–like cells, inhibiting the proteasome or autophagy reshapes extracellular vesicle cargo and spreads proteotoxic stress to recipient cells.
UVB triggers disulfidptosis in skin cells, driving photodamage and photoaging
A new study reports that UVB radiation kills keratinocytes through NCKAP1-mediated disulfidptosis, and that blocking this pathway with TCEP mitigates ...
Stress-triggered mitochondrial protein aggregates relay quality-control signals to the ER
Researchers report that stressed mitochondria form protein aggregates called SIMPAs that signal through GRP75 at mitochondria–ER contact sites to trigger ...
Hidden Protein Shield Helps Lung Tumors Survive Osimertinib Treatment
A new study shows that ZNF593-driven SUMOylation stabilizes the stress-responsive protein ANKRD1, which activates MERTK-AKT survival signaling and promotes acquired ...
Cold-triggered muscle metabolism promotes longevity in worms
Moderately cold temperatures trigger a metabolic pathway in the nematode Caenorhabditis elegans that increases lifespan and supports protein homeostasis, according ...
Excess ASNS links neuronal stress to Angelman syndrome features in mice
Reducing excess asparagine synthetase in a mouse model of Angelman syndrome restored protein synthesis and improved microcephaly and many behavioural ...
Cold triggers a muscle-to-tissue metabolic network in worms
A nematode study shows how cold-induced BH2 production in muscle coordinates longevity and protein homeostasis across distant tissues.
Unstressed yeast study links Zuo1 surveillance to predicted protein disorder
A study in unstressed yeast found that loss of the ribosome-associated chaperone Zuo1 allowed transcripts encoding more disordered proteins to ...
Cellular Recycling Pathway Slows Aging by Keeping Senescent Cells in Check
Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of ...
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