Tag: preclinical models

A narrative review argues that MEK inhibitors have transformed treatment of NF1-associated plexiform neurofibromas, but predominantly partial responses, toxicity, and ...

Engineered CAR-T cells equipped with a synthetic radiation-inducible promoter locally release tumor necrosis factor upon tumor irradiation to enhance antitumor ...

A comprehensive review finds that Traditional Chinese Medicine formulas and compounds modulate multiple pathological processes in radiation enteropathy, yet clinical ...

A new mini review describes how the polyamine spermidine can both fuel colorectal cancer growth through the MYC–ODC–eIF5A circuit and, ...

A zinc-chelating dye that stains insulin-producing beta cells red allowed researchers to locate and retrieve otherwise invisible islet grafts transplanted ...

Preclinical research shows serine supplementation, rather than restriction, suppresses tumor growth and reinvigorates CD8+ T cells by countering tumor cell ...

Engineered IL-6-responsive CAR macrophages enhanced CAR-T cell antitumor activity, matrix remodeling, and survival in preclinical solid tumor models.

A comprehensive review finds that natural products modulate inflammation, barrier repair and itch in atopic dermatitis models, but warns that ...

A new review evaluates the cellular and animal models used to study Bandavirus dabieense infection and argues that no single ...

A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting ...

A new review synthesizes preclinical evidence that traditional Chinese medicine monomers and decoctions can rebalance Th17-driven immune responses in ulcerative ...

A new review proposes that TNF-α and IL-6 act as a self-amplifying inflammatory axis in cancer pain, while stressing that ...

New research from MD Anderson shows the METTL13 enzyme helps cancer cells selectively produce growth-driving proteins such as KRAS, and ...

A screen of over 1400 FDA-approved compounds identified topoisomerase I inhibitors as the most effective partners for PARP inhibitors in ...

A new critical review finds that silymarin shows broad preclinical antifibrotic activity across multiple organs, but heterogeneous formulations, low oral ...

Sustained blood CXCL1 elevation tracked attenuated Salmonella colonization in four preclinical tumor models.

A biomimetic coacervate that binds cartilage, lubricates joints and delivers anti-inflammatory drugs and stem cells reduced cartilage degradation in rat ...

A gemcitabine-modified tumor-suppressor microRNA called Gem-miR-15a overcame 5-FU and oxaliplatin resistance in preclinical colorectal cancer models with low-nanomolar potency and ...

A peer-reviewed study associated elevated circulating B cells before treatment with increased risk of immune checkpoint inhibitor–related colitis and found ...

A preclinical study found that SIRPα signaling inside triple-negative breast cancer cells promoted mitochondrial fission, motility, immune tolerance and brain ...