Serotonin Receptor in Brain Macrophages Boosts Debris Clearance After Stroke
A mouse and human study identifies an Htr2b-positive macrophage subset in the ischemic brain whose serotonin-driven lysosomal activity supports debris ...
Tag: Neuroinflammation
Astrocyte Lipid Metabolism Emerges as a Central Player in ALS Progression
A new review argues that disrupted lipid handling in astrocytes may amplify motor neuron injury and disease progression in ALS.
Witnessing Defeat Is Not the Same as Suffering It: Mouse Study Shows Two Stress Models Diverge
A controlled mouse study finds that witnessed social defeat produces overlapping but distinct behavioral and hippocampal molecular effects from direct ...
NF-κB1 Emerges as a Context-Dependent Switch in Neurodegenerative Disease
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and ...
Immunoglobulins and Efgartigimod dampen neuronal activity in rat cortical cultures
Primary rat cortical neurons express FcγRIIb and FcRn, and both immunoglobulins and the FcRn blocker Efgartigimod reduced neuronal activity in ...
Plasma exchange cuts amyloid plaques in aged Alzheimer’s model mice
A mouse study reports that monthly plasma exchange with albumin, started at an advanced stage of amyloid pathology, reduced insoluble ...
Removing Prion Protein from Human Astrocytes Alters Reactivity and Mitochondria but Not Neuronal Support
A new human cell model shows that astrocytes lacking the prion protein display increased reactivity markers and mitochondrial abnormalities, yet ...
Astrocyte-Derived Peptide Analog Shields Dopaminergic Neurons in Parkinson’s Mouse Model
A single intracerebroventricular dose of the ODN analog OP preserved tyrosine hydroxylase-positive neurons and reduced oxidative stress, inflammation, and miRNA ...
Asthma Drug Montelukast Shields Nerve Cells from Parkinson-Like Damage in Lab Study
A new cell study reports that montelukast, a common asthma medication, protected human neuroblastoma cells from rotenone-induced toxicity by modulating ...
Stem cell therapies show promise for Alzheimer’s disease, but clinical evidence remains limited
A new review finds stem cell and extracellular vesicle therapies show encouraging preclinical results for Alzheimer's disease, but published clinical ...
Varenicline’s molecular mechanisms in neuropsychiatric disorders reviewed
A new review examines how the α4β2 nicotinic receptor agonist varenicline might act on molecular pathways involved in neuropsychiatric disorders.
Astrocyte Stress Protein NDRG2 Emerges as a Candidate Target in Depression Review
A new review proposes that the astrocytic stress-responsive protein NDRG2 coordinates multiple depression-related pathways and may serve as a precise ...
Monocytes, Not T Cells, Show Strongest Gene Disruption in Multiple Sclerosis
A reanalysis of bulk RNA-sequencing data from multiple sclerosis patients finds that CD14+ monocytes show the most extensive transcriptional and ...
Cell Study Finds lncRNA-Derived Peptide Curbs IL6-Driven Inflammation via HMGA2
A laboratory study in LPS-stimulated HMC3 cells reports that the lncRNA-derived peptide ZNF503-AS-Pep1 reduces IL6 transcription and oxidative damage by ...
Gut Microbe Metabolites Sharpen Prediction of Stroke Worsening After Thrombolysis
A prospective single-center study found that adding gut-derived tryptophan metabolites and interferon gamma to blood pressure and glucose raised the ...
Deleting TBK1 Entirely Slows Disease Progression in ALS Model Mice
Complete deletion of the ALS-linked gene TBK1 suppresses microglial activation and extends disease duration in SOD1-ALS model mice, a new ...
Electroacupuncture Eases Cognitive Impairment in Schizophrenia Model Mice
A preclinical mouse study reports that electroacupuncture at the ST36 acupoint improved recognition memory over three weeks while suppressing neuroinflammation ...
Hericium erinaceus polysaccharide ameliorates spatial working memory impairment and intestinal barrier dysfunction in high-fat high-sucrose diet-fed mic
A lion's mane mushroom polysaccharide partially reversed metabolic, intestinal barrier, and spatial memory deficits in mice fed a high-fat, high-sucrose ...
Dragon’s Blood Resin Shows Preclinical Promise for Protecting Post-Stroke Memory
A new review finds that Dragon's Blood resin and its active components show multi-target protective effects against ischemia-induced memory impairment ...
Time matters: CB2 receptor, developmental stress sensitivity and affective vulnerability
A new review synthesizes evidence that the CB2 cannabinoid receptor is dynamically remodeled by early-life and adolescent adversity in a ...
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