Tag: Neuroinflammation

Targeted oral stimulation of free fatty acid receptor 2 suppresses established central nervous system autoimmunity in rodent models by triggering ...

Long-term TNFR2 agonist treatment produced distinct neuropathological, glial, and cognitive responses in male and female 3xTg-AD mice without altering amyloid ...

A retrospective study of 11 hospitalized patients details the varied clinical manifestations, cerebrospinal fluid markers, and cranial imaging abnormalities associated ...

Researchers identified nitric oxide synthase 2 as a possible molecular link between air pollutant exposure and biological pathways implicated in ...

A study in Fluids and Barriers of the CNS finds that APPswe/PS1dE9 mice show no major integrative brain clearance deficits ...

A review in npj Parkinson's Disease examines the brain lymphatic drainage system's role in Parkinson's disease pathogenesis.

Proteomic analysis of aging macaques reveals region-specific molecular changes following chronic GCPII inhibition, highlighting potential therapeutic targets for sporadic Alzheimer's ...

A human clinical trial reveals that the reactive astrogliosis PET tracer SMBT-1 displays an effective radiation dose comparable to established ...

A new study using SIMOA assays finds that elevated CSF phosphorylated PKR levels in Alzheimer’s disease are associated with APOE4 ...

A combination of ezetimibe and sericin alleviated cadmium chloride-induced neurotoxicity, oxidative stress, and neuroinflammation in an experimental rat model.

A single-cell transcriptomic study in mice reveals how periodontal inflammation exacerbates neuroinflammatory signaling and alters glial cholesterol pathways in early ...

A review in Aging Cell details how histone modifications link aging, metabolism, and neuroinflammation in Alzheimer's disease, proposing a framework ...

A study in Acta Neuropathologica Communications finds that early blood-brain barrier and glial changes in 3xTg-AD mice correlate with anxio-depressive-like ...

A review published in Discover Immunity synthesizes evidence on the immunological mechanisms and neuroinflammatory pathways driving amyotrophic lateral sclerosis alongside ...

A new review in Molecular Biology Reports synthesizes in vitro, animal, and clinical evidence on six molecular mechanisms by which ...

A five-year NIH grant will support research examining how sleep health, lipid-derived inflammatory mediators, and neighborhood conditions influence cognitive decline ...

A new review compares cerebral amyloid angiopathy-related inflammation with primary angiitis of the central nervous system, showing they overlap clinically ...

A new review in Frontiers in Pharmacology evaluates how microbial metabolites may mediate chemotherapy-induced cognitive impairment, providing a framework for ...

Researchers developed an injectable reactive oxygen species-responsive nanoscaffold delivering mesenchymal stem cell-derived nanovesicles that reduced inflammation, mitigated oxidative stress, and ...

A whole-exome sequencing study of a multigenerational family identified candidate gene variants linked to dopaminergic signalling, neuroinflammation, and folate metabolism ...