Tag: mouse models

In a study of female mice, beta-alanine supplementation partially attenuated symptoms of glucocorticoid excess and preserved glucose tolerance.

A sequential regimen combining chemical carcinogens and a Western diet reliably produces advanced hepatocellular carcinoma in male and female mice ...

An optimized on-tissue derivatization workflow using 4-APEBA and EDC enables confident MALDI-MSI mapping of carbonyl- and carboxyl-containing metabolites in mouse ...

A new computational framework called TopoBoW combines topological data analysis with visual word encoding to distinguish healthy from pathological mouse ...

Genetic screens in aged mice identify Dusp5 and Zfp219 as regulators whose deletion can restore anti-tumor T cell function, with ...

A mouse study identifies the mitochondrial enzyme CMPK2 as a key mediator of doxorubicin heart injury and reports that flavin ...

New mouse experiments show that losing the tumour suppressor Apc in pituitary stem cells is enough to cause adamantinomatous craniopharyngioma ...

Autophagy in alveolar macrophages restrains IL-1α production, and blocking it primes innate immunity that speeds clearance of bacterial and viral ...

A serpin called miropin made by Tannerella forsythia inhibits the gingipain K protease of Porphyromonas gingivalis, reducing its growth and ...

An engineered compact Cas12m variant enables multiplexed CRISPR gene activation from a single AAV vector in mouse models.

Loss of PTEN makes T-cell acute lymphoblastic leukemia cells dependent on the guanylate-synthesis enzyme IMPDH, allowing clinically approved IMPDH inhibitors ...

A mouse study finds that IL-2-producing TFH cells sustain regulatory T cells in gut-associated lymphoid tissues, and their loss triggers ...

A new study reports that inhibiting the protein TXNIP in pulmonary vascular endothelial cells attenuates pulmonary hypertension and vascular remodeling ...

A mouse study finds that the transcription factor Sox3 preserves the actin core of hair cell stereocilia, and that its ...

Mouse experiments show that CD4+ T cells license CD8+ T cells through CD40 signaling, enabling combination immunotherapy to eliminate mismatch ...

A new mouse tool reveals that CD51-positive astrocytes are a functionally distinct subpopulation that promotes cortical synapse formation, hippocampal circuit ...

A mouse study finds that progranulin deficiency impairs cathepsin D enzymatic activity despite elevated protein levels, disrupts lysosomal organization, and ...

VCU Massey researchers found that blocking sphingosine kinase 2 specifically in fat cells reduced body weight and improved metabolic health ...

A preclinical mouse study found that engineered Lactococcus lactis linked to T cells improved tumor localization, coordinated local immune activity ...

The Partita CRISPR activation library identified Irx5 as a gene linked to venetoclax resistance and Runx2, Runx3 and Csf1r as ...