Tag: mouse models

Mandimycin M16 neutralized 11 priority fungal pathogens in vitro and outperformed amphotericin B in mouse models of systemic Candida infection ...

A mouse study shows that CD51-positive and CD51-negative astrocytes have distinct roles in synapse formation, memory-circuit adaptation and recovery from ...

An experimental comparison of 17 autism-risk mouse lines identified two opposing brain-gene activity states that varied with sex, development and ...

Blocking asparagine synthetase restored brain growth and behaviors in Angelman syndrome mice by interrupting persistent neuronal stress signaling downstream of ...

Researchers in Barcelona report that a six-gene activity score, anchored by the Polycomb factor PHF19, divides acute myeloid leukaemia patients ...

Microparticles made from red blood cells deliver haem to the nucleus of dendritic cells, activating a pathway that boosts cytotoxic ...

A mouse study found that removing ANKRD11 enhanced CD8+ T-cell activity against chronic hepatitis B virus infection and cancer, but ...

In mouse cerebellar slice cultures, blocking mGluR1 partially restored dendritic, spine and postsynaptic abnormalities in Purkinje cells carrying the SCA14-associated ...

Mouse infection experiments show that Mycobacterium tuberculosis remains difficult for innate immunity to clear across ultra-low-dose, microbiota-primed, and Legionella-primed models.

Researchers report that mouse and human beige adipocytes can increase energy expenditure through a futile sodium and potassium transport cycle ...

A mouse study found that organized immune hubs in skull bone marrow respond to nervous-system antigens and influence tumor immunity ...

A mouse study found that directly reducing lung cancer cells’ dependence on phospholipase D1 significantly slowed tumor growth, but clinical ...

An experimental study in ALS models found that an interferon-beta signal can increase motor-neuron immunoproteasome activity and clear aggregation-prone TDP-43 ...

SGK1 inhibition reduced fibrosis and airway obstruction in a mouse bronchiolitis obliterans model and suppressed fibrosis-related molecular changes in human ...

Human postmortem tissue, cultured cells and mouse experiments implicated abnormal ABCA1-dependent cholesterol trafficking in Parkinson’s-related neurodegeneration.

An L-alanine-functionalized, virus-like mesoporous silica carrier improved antibiotic delivery and therapeutic outcomes in mouse models of bacterial meningitis.

Cell, tissue and mouse experiments link elevated SWAP70 to advanced human liver tumors and show that it supports hepatocellular carcinoma ...

IKKε deficiency reduced pain-related behavior and synovitis in mouse osteoarthritis models without producing a statistically significant reduction in cartilage degeneration.

A cross-species single-cell and spatial transcriptomics study reveals a conserved Notch/AP-1 to fibronectin and thrombospondin signaling axis operating in a ...

New research shows that two mutations of the α5 nicotinic receptor gene produce opposing empathy-related behaviors in mice, mirroring distinct ...