Tag: Liver Fibrosis

Explainable machine-learning models built from routine clinical variables outperformed conventional fibrosis scores for identifying significant fibrosis in adults with MASLD ...

A narrative perspective indicates that lean individuals with metabolic dysfunction-associated fatty liver disease face substantial hepatic, cardiovascular, and malignancy risks ...

A preclinical study demonstrates that combining shear wave elastography and ultrasound localization microscopy improves noninvasive liver fibrosis staging in rats ...

A three-point hepatic vulnerability score combining hyperbilirubinemia, fibrosis and steatosis was independently associated with post-hepatectomy liver failure and major complications ...

Mouse hepatocyte extracellular vesicles deliver microRNA-122-5p to hepatic stellate cells, suppressing NRF1 and GPX4 to drive ferroptosis and reduce fibrogenesis.

A prospective study across seven European nations reveals that metabolic dysfunction-associated steatotic liver disease accounts for nearly a quarter of ...

A nationwide cross-sectional study in Türkiye found that FIB-4 scores negatively correlated with cardiometabolic risk factors in older adults, limiting ...

Circulating levels of the angiogenesis inhibitor endostatin are selectively reduced in chronic hepatitis C patients without steatosis and normalize following ...

In cholestatic rat liver, blocking the p38 MAPK pathway significantly reduced the rise of high-ploidy hepatocytes after bile duct ligation, ...

A rat study reports that intravenous human umbilical cord mesenchymal stem cells improved liver function, reduced steatosis and fibrosis, and ...

A 25-week Indian cohort study found both saroglitazar and dapagliflozin improved liver fat and metabolic markers in MASLD patients, with ...

A traditional Chinese medicine formula reduced liver fibrosis in rat and cell models by down-regulating the PI3K/AKT signaling pathway, according ...

A case-control study in Egypt found that serum liver fatty acid-binding protein distinguished MASLD patients from healthy controls with high ...

A new review proposes the MMCK syndrome, an operational extension of the CKM framework that integrates MASLD liver fibrosis scoring ...

Researchers meeting in Nanchang reported new mechanisms of TGF-β signaling in stem cell differentiation, cancer, fibrosis and immunity, alongside inhibitors ...

A new narrative review maps how the bile acid TUDCA relieves ER stress, inflammation, oxidative damage, and apoptosis in liver ...

An 11-protein signature from circulating extracellular vesicles, validated in an independent cohort, was associated with advanced fibrosis in MASH and ...

A cross-sectional study of 50 Egyptian infants found that all children with biliary atresia were vitamin D deficient or insufficient, ...

An integrative RNA sequencing and machine learning study identified a seven-gene signature and key liver cell subpopulations associated with advanced ...

A new critical review finds that silymarin shows broad preclinical antifibrotic activity across multiple organs, but heterogeneous formulations, low oral ...