Bacteriophages Show Potential as Zinc Oxide Alternative Against Piglet Diarrhea
A multi-omics study found that bacteriophage treatment reduced diarrhea in ETEC K88-infected weaned piglets while shifting gut bacteria, bile secretion, ...
Tag: ferroptosis
Blocking a Nerve-Linked Ion Channel Turns Tumor Cell Stress Into Fatal Ferroptosis
A preclinical nanoplatform that blocks the TRPA1 ion channel while delivering glucose starvation, chemodynamic, and sonodynamic therapy suppressed tumor growth ...
Tumor-derived exosomes drive cochlear hair cell ferroptosis in vestibular schwannoma
Vestibular schwannoma-derived exosomes suppress GPX4 and disrupt iron homeostasis, triggering ferroptotic death of cochlear hair cells that a ferroptosis inhibitor ...
Iron Overload, Ferroptosis and the Liver: Mapping a Deadly Network
A new review maps how disrupted iron homeostasis and ferroptosis drive liver disease, from hereditary hemochromatosis to hepatocellular carcinoma, and ...
FOXA1 Keeps Cervical Cancer Cells Alive by Blocking Ferroptosis Through SLC7A11
A new study finds that the transcription factor FOXA1 suppresses ferroptosis in cervical cancer cells by directly activating SLC7A11 transcription, ...
IGF2BP3 stabilizes TROAP mRNA and suppresses ferroptosis in non-small cell lung cancer
A new study reports that the m6A reader protein IGF2BP3 promotes non-small cell lung cancer progression by stabilizing TROAP mRNA ...
One Fat-Activating Enzyme Emerges as a Common Thread in Female Reproductive Disease
A new review finds that ACSL4 currently has the strongest disease-specific evidence among long-chain acyl-CoA synthetases across six female reproductive ...
Kurarinone curbs neuronal ferroptosis via ERα–NRF2/FTH1 pathway in Parkinson’s models
Kurarinone protected neurons from ferroptosis in cellular and mouse models of Parkinson's disease by activating an ERα-associated NRF2/FTH1 iron-sequestration pathway.
Metabolic Protein Tags Emerge as Key Players in Disc Degeneration
A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...
ACTN4 protein target disrupts iron recycling and triggers ferroptosis in leukemia cells
A new open-access study shows that pseudolaric acid B binds ACTN4, disrupting TfR1 recycling and driving iron-dependent ferroptosis in acute ...
Cell Study Links RNA Modification WTAP to KDR Protection in Aneurysm Model
A cell study finds that WTAP upregulates KDR through m6A modification, protecting human brain microvascular endothelial cells from angiotensin II-induced ...
ADP-ribose, an NAD+ catabolite, drives neuronal ferroptosis through ENT2 inhibition
A new Nature Chemical Biology study identifies the NAD+ catabolite ADP-ribose as an inducer of neuronal ferroptosis through inhibition of ...
Beyond Apoptosis: How Inflammatory Cell Death Pathways Shape Autoimmune Disease
A review in Molecular Biology Reports describes how pro-inflammatory forms of regulated cell death, including ferroptosis, pyroptosis and necroptosis, contribute ...
Low thyroid hormone triggers liver cell ferroptosis in congenital hypothyroidism study
A pig model of congenital hypothyroidism reveals that thyroid hormone deficiency impairs an antioxidant signaling axis in the liver, promoting ...
Rethinking High-Altitude Retinopathy as a Spectrum of Vascular and Neural Responses
A new review reframes high-altitude retinopathy as an adaptation–mismatch–decompensation spectrum and finds that proposed natural compounds remain preclinical.
Scientists discover a durable molecular fingerprint of ferroptosis in cells and blood
A reducing reagent-resistant dimer of transferrin receptor 1 emerges during lipid peroxidation and can be detected in tissues and blood-borne ...
Dialysis-Based Iron Removal Shows Feasibility in Pig Model of Sepsis-Linked Kidney Injury
A pilot study in three pigs found that a chelating polymer added to dialysate could extract labile iron during continuous ...
Switchgrass microbe’s extracts show selective growth-stopping activity against tumor cells
Crude extracts of the switchgrass-associated bacterium Bacillus proteolyticus OSUB18 stopped the growth of diverse solid tumor cell lines in laboratory ...
Long Noncoding RNA SNHG4 Emerges as a Player Across Multiple Human Cancers
A new review consolidates reported expression patterns, mechanisms, and clinical potential of the long noncoding RNA SNHG4 across six cancer ...
Acute versus chronic liver disease drives different cardiac injury programmes, review proposes
A new review proposes an 'acute storm versus chronic siege' framework distinguishing how acute and chronic liver disease injure the ...
