Chemical Tag on RNA Helps Melanoma Dodge Ferroptosis, Study Finds
New research shows that the m6A reader protein YTHDF2 promotes melanoma progression by destabilizing HMOX1 mRNA and shielding tumor cells ...
Tag: ferroptosis
PET tracer lights up ferroptosis to track liver cancer immunotherapy in real time
Researchers combined anti-PD-L1 immunotherapy with the PARP inhibitor Olaparib to trigger ferroptosis in liver cancer and used the SLC7A11-targeted PET ...
Diabetes Drug Metformin Surprisingly Blocks Ferroptotic Cell Death in Cancer Cells
New research shows that metformin and phenformin suppress cysteine deprivation-induced ferroptosis in cancer cells by dampening mitochondrial hyperpolarization, oxygen consumption, ...
Triaptosis: Scientists Unveil a New Form of Cell Death Centered on Endosomes
A new review in Cell Death & Discovery proposes triaptosis, an endosome-centered form of ROS-regulated cell death driven by oxidative ...
Kidney Disease in Newborn Mice Drives Iron Buildup in the Developing Brain
A new mouse study shows that severe kidney disease in newborns causes iron to accumulate throughout the developing brain, offering ...
Stevia Extract Shields Diabetic Livers by Taming Iron-Driven Cell Death
A new rat study shows aqueous stevia extract protects diabetic livers by suppressing ferroptosis, boosting antioxidant enzymes, and reducing inflammation.
Copper Overload Silences a Key Liver Fat Gene, Pushing Cells Into Ferroptosis in Wilson Disease
New research shows that copper accumulation in Wilson disease shuts down the PPARα–FABP1 fat-handling axis in hepatocytes, sensitizing them to ...
Bacterial Toxin Hijacks Mitochondria to Trigger Fatal Cell Death in Bovine Mastitis
New research reveals that the Staphylococcus aureus virulence factor Sph disrupts mitochondrial cristae through Mic60, releasing mtDNA that activates the ...
Astrocyte Redox Switch Linked to Synapse Damage in Multiple Sclerosis
A new single-cell and animal study links SLC7A11-high astrocyte states to antioxidant failure and synaptic remodeling in multiple sclerosis, pointing ...
Orphan Nuclear Receptor Ligands Trigger Ferroptosis and Reshape Immunity in Colon Cancer
New research shows that synthetic ligands for the orphan nuclear receptors NR4A1 and NR4A2 induce iron-dependent cell death in colon ...
Iron and Copper Cell Death Pathways May Hold Key to Beating Immunotherapy Resistance
A new review in Medical Oncology argues that simultaneously inducing the iron-driven cell death ferroptosis and the copper-driven cuproptosis, tuned ...
How a Common Grain Toxin Hijacks Cells—and How Probiotics Fight Back
A new review maps how the mycotoxin deoxynivalenol hijacks ribosomal and cellular signaling networks to drive intestinal, immune, neurological and ...
Gut Metabolite 2,8-Dihydroxyquinoline Shields Sperm Cells From Iron-Driven Cell Death
A gut microbiota-derived antioxidant metabolite, 2,8-dihydroxyquinoline, reverses oligoasthenozoospermia in mice by binding the kinase MAPK14 and blocking ferroptotic death of ...
Nerve Fibers Invade the Aging Lens, Revealing How Cataracts Take Hold
A single-cell atlas of 554 human cataract capsules reveals that nerve-like fibers invade the aging lens through an NRG1-ERBB3 signaling ...
Cellular Contact Points Called MAMs Emerge as Central Players in Heart Attack Damage
A new review in the Journal of Translational Medicine argues that mitochondria-associated endoplasmic reticulum membranes integrate lipid metabolism and ferroptosis ...
Iron-Powered Cell Death Emerges as Double-Edged Sword in Cancer’s Microenvironment
A new review in Medical Oncology maps how the tumor microenvironment can either amplify or suppress ferroptosis, the iron-dependent cell ...
Iron, Inflammation, and a Deadly Paradox: Rethinking Cancer Wasting Through Ferroptosis
A new iScience review argues that ferroptosis, an iron-driven form of cell death, links tumor and immune signals to muscle ...
Lactate Fuels a Deadly Feedback Loop That Drives Gut Damage in Ulcerative Colitis
A new study in Genome Medicine reveals that lactate produced by inflamed gut cells fuels an ACSS2-driven histone lactylation feedback ...
A Lipid Dial May Decide Whether Bile Duct Cancer Cells Live or Die by Ferroptosis
A new review proposes that the ratio of monounsaturated to polyunsaturated membrane phospholipids acts as a tunable rheostat controlling ferroptosis ...
Cancer Cells Rewire Immune Neutrophils Through a Fumarate-Driven Metabolic Switch, Study Finds
A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...
