3D Tumor Models Expose How Biliary Tract Cancers Evade Chemotherapy
A new review argues that three-dimensional tumor models, including patient-derived organoids, can reveal the drug resistance and apoptosis evasion mechanisms ...
Tag: ferroptosis
Ribosomal RNA Tag and a Detox Enzyme Form a Deadly Cancer Survival Circuit
A new review describes how the RNA methyltransferase METTL5 and the detox enzyme MGST1 form a signaling axis that helps ...
Gut Microbe Molecule 7-KDCA Shields Diabetic Muscles by Blocking NLRP1-Ferroptosis Cell Death
Researchers found that the gut bacterial metabolite 7-KDCA protects against diabetic muscle wasting by suppressing NLRP1 inflammasome activation and ferroptosis ...
Ancient Growth-Control Pathway Emerges as a Master Switch of Brain Ageing
A new review in Biogerontology argues that the Hippo–YAP/TAZ signalling pathway acts as a central hub linking brain ageing, neurodegeneration, ...
Oxidative Stress Takes Center Stage in Vitiligo as Scientists Target the Nrf2 Antioxidant Pathway
A new review in the Archives of Dermatological Research positions oxidative stress and the Nrf2 antioxidant pathway at the center ...
Fat Rewrites the Rules of Liver Cancer Across Every Disease Stage
A new review proposes that lipid metabolism plays fundamentally different roles at each stage of fatty liver disease progression to ...
Iron’s Dark Side: How Ferroptosis Drives Brain Disease and What Could Stop It
A new review proposes the Iron-Brain Nexus framework to explain why the brain is uniquely vulnerable to iron-dependent ferroptotic cell ...
Stroke Drug’s Success May Hinge on the Brain’s Hidden Backup Blood Vessels
A Duke University preclinical study finds that the experimental ATM inhibitor AZD1390 reduced stroke-related brain injury in mice only when ...
Injectable Seaweed Hydrogel Powered by Bimetallic Nanozymes Turns Pancreatic Tumors Into Immune Training Grounds
A marine polysaccharide hydrogel loaded with a zinc-iron MOF nanozyme and glucose oxidase induces ferroptosis and activates cGAS-STING immunity to ...
Iron, Lipids and Cell Death: Ferroptosis Biomarkers Emerge as Clues to Vitiligo Activity
A new case-control study finds that serum markers of ferroptosis, including ACSL4, MDA and ROS, are elevated in vitiligo vulgaris ...
Circular RNA circLPAR3 blocks ferroptosis to fuel chemotherapy resistance in prostate cancer
Researchers at Nanjing Medical University report that the m6A-stabilized circular RNA circLPAR3 suppresses ferroptosis through the PCBP2/CHAC1 axis, driving docetaxel ...
MOTS-c: The Tiny Mitochondrial Peptide That Behaves Differently in Health and Cancer
A new review argues that the mitochondrial peptide MOTS-c acts as a context-dependent stress signal with protective roles in metabolic ...
Scientists Uncover How Oral Cancer Cells Outsmart Cisplatin by Blocking Ferroptosis
New research reveals that the secreted protein DKK1 helps oral squamous cell carcinoma resist cisplatin by keeping the SLC3A2 cystine ...
Gated Nanoreactor Turns Tumor Glucose Into Carbon Monoxide to Boost Mild Heat Therapy
A ZIF-8-gated cascade nanoreactor converts tumor glucose into hydrogen peroxide and carbon monoxide, depleting ATP and suppressing HSP70 so that ...
Chemical Tag on RNA Helps Melanoma Dodge Ferroptosis, Study Finds
New research shows that the m6A reader protein YTHDF2 promotes melanoma progression by destabilizing HMOX1 mRNA and shielding tumor cells ...
PET tracer lights up ferroptosis to track liver cancer immunotherapy in real time
Researchers combined anti-PD-L1 immunotherapy with the PARP inhibitor Olaparib to trigger ferroptosis in liver cancer and used the SLC7A11-targeted PET ...
Diabetes Drug Metformin Surprisingly Blocks Ferroptotic Cell Death in Cancer Cells
New research shows that metformin and phenformin suppress cysteine deprivation-induced ferroptosis in cancer cells by dampening mitochondrial hyperpolarization, oxygen consumption, ...
Triaptosis: Scientists Unveil a New Form of Cell Death Centered on Endosomes
A new review in Cell Death & Discovery proposes triaptosis, an endosome-centered form of ROS-regulated cell death driven by oxidative ...
Kidney Disease in Newborn Mice Drives Iron Buildup in the Developing Brain
A new mouse study shows that severe kidney disease in newborns causes iron to accumulate throughout the developing brain, offering ...
Stevia Extract Shields Diabetic Livers by Taming Iron-Driven Cell Death
A new rat study shows aqueous stevia extract protects diabetic livers by suppressing ferroptosis, boosting antioxidant enzymes, and reducing inflammation.
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