Tag: drug resistance

BRAF inhibitor-resistant melanoma cells release M-CSF and remodel the immune microenvironment, and blocking this signal improved drug efficacy in mouse ...

A systematic review of 51 studies finds recurring metabolic signatures linked to malaria severity, drug pressure and mosquito transmission, while ...

A new study reports that combining the multi-target kinase inhibitor cediranib with KRASG12C inhibitors overcomes resistance by sustaining ERK blockade, ...

A new review details how the pan-RAS inhibitor daraxonrasib doubled overall survival in a phase III pancreatic cancer trial and ...

A ten-year analysis of 9,665 tuberculosis isolates from Zhengzhou, China, finds overall drug resistance rising from 17.29 percent to 22.98 ...

Laboratory screening of compounds isolated from Jatropha curcas roots identified curcusones B and C as potent, slow-acting inhibitors of Plasmodium ...

New research shows that removing the chromatin remodeler ALC1 sensitizes a broad range of ovarian cancer models to PARP inhibitors ...

A genome-wide CRISPR screen identifies UGCG-driven sphingolipid metabolism and protective autophagy as drivers of Niraparib resistance in ovarian cancer.

A new cell-culture study reports that an EGFR-IL-8 signaling loop between liver cancer cells and macrophages sustains lenvatinib resistance in ...

A new review maps the advances in diagnosing and treating cholangiocarcinoma while highlighting persistent gaps in early detection, drug resistance ...

The experimental compound ISFP10, which selectively inhibits a fungal-specific cell wall enzyme, showed potent activity against Candida strains in vitro ...

A review in Discover Oncology describes how the gut microbiota can modulate chemotherapy efficacy and resistance through drug sequestration, metabolic ...

A Belgian case report traced virological failure of long-acting cabotegravir/rilpivirine to an NNRTI resistance mutation archived in proviral DNA 41 ...

Targeted sequencing of 83 respiratory specimens in Jiangxi, China, found MTC/NTM co-detection in about a quarter of patients and genotypically ...

An interim analysis of the BORTEM-17 phase IB/II trial found that sequential bortezomib and temozolomide achieved disease control in four ...

A study analyzing 699 M. tuberculosis isolates from 2018 and 2023 in Ecuador found only one Beijing sublineage isolate, which ...

A new review argues that glucose, lipid, and amino acid metabolism form one interconnected network driving hepatocellular carcinoma growth, immune ...

A new review outlines how the copper-dependent cell death regulator FDX1 may shape prognosis, metabolism, and treatment resistance in triple-negative ...

A French National Reference Centre study of 234 Brucella isolates validates the EUCAST 2026 clinical breakpoints using routine susceptibility testing ...

A systematic review and meta-analysis of 36 studies estimates that roughly one in three carbapenem-resistant Pseudomonas aeruginosa clinical isolates is ...