Tag: drug resistance

A surveillance study of 699 tuberculosis isolates from Ecuador found the drug-resistance-associated RDRio genotype at 5.72 percent prevalence, stable from ...

A national genomic survey of 1,281 Mycobacterium tuberculosis isolates reveals four major lineages, high isoniazid and rifampicin resistance, and the ...

A new editorial argues that extracellular vesicles both drive tumor adaptation and drug resistance and offer promising platforms for antitumor ...

Whole-genome sequencing of 51 Mycobacterium africanum isolates reveals substantial sub lineage diversity across Senegal and complete concordance between sequencing-based and ...

A new semi-automated imaging assay that monitors the motility of Fasciola hepatica juveniles identified three nanomolar-potent salicylanilide hits, though only ...

Genome sequencing of normal oesophageal tissue shows that chemotherapy and chemoradiotherapy select for distinct mutant clones in healthy cells, including ...

A new study shows that ZNF593-driven SUMOylation stabilizes the stress-responsive protein ANKRD1, which activates MERTK-AKT survival signaling and promotes acquired ...

A five-year National Cancer Institute grant will fund laboratory research into response biomarkers and resistance mechanisms for TROP2-targeted antibody-drug conjugates ...

A systematic review and meta-analysis found expanding artemisinin-resistance markers in East Africa, declining partner-drug markers in pooled data and pronounced ...

A study of 278 treatment-naive people with HIV-1 found high viral susceptibility to recommended first-line drugs and clinically relevant NRTI ...

A review of clinical and preclinical evidence finds that antibody–drug conjugates can improve outcomes with immune checkpoint inhibitors in several ...

A preclinical study reports that combining the CD44v6 inhibitor AMC303 with the dual PI3K/mTOR inhibitor Apitolisib suppresses HGF-driven reprogramming and ...

A focused preclinical review finds that natural products can suppress NRF2-linked antioxidant defenses in hepatocellular carcinoma while protecting non-malignant liver ...

University of Michigan researchers report that the molecular glue RPT04402 stabilizes the trimeric tumor suppressor PP2A, shrinking KRAS-mutant lung tumors ...

A 2026 review finds that bacteriophages can selectively alter gut bacteria, but durable human microbiome reconstruction remains unproven.

A narrative review links heat shock proteins to gastric cancer invasiveness, resistance and immune modulation, but finds that most therapeutic ...

A review finds that HOTAIR links chromatin remodeling, tumor progression, metabolic adaptation and treatment resistance through functions that vary by ...

Ailanthone reduced HSV-1 replication in cell models and eased corneal disease in mice, with experiments implicating reduced expression of the ...

A comprehensive review finds that AML cells commonly overcome epigenetic drugs through compensatory chromatin and transcriptional adaptation, favoring biomarker-selected combinations ...

Preclinical hepatocellular carcinoma models showed that blocking ACSS2 or autophagy enhanced cabozantinib’s antitumor activity by disrupting a TFEB-linked protective response.