Tag: drug resistance

A review highlights Histone Deacetylase 1 as a promising epigenetic target to address drug resistance and poor prognosis in cholangiocarcinoma.

A review in Molecular Cancer examines how antibody-drug conjugates treat solid tumors while addressing clinical resistance, toxicity profiles, and narrow ...

A review evaluates the SLC7A11-ferroptosis axis in BRCA1-mutant breast cancer, highlighting preclinical therapeutic potential alongside critical gaps in resistance mechanisms.

A narrative review argues that PEAK1 acts as a context-dependent signaling scaffold in adhesion, growth factor pathways, metastasis and drug ...

A new review maps how the m7G RNA modification acts across distinct RNA compartments to drive codon-biased translation, tumor adaptation, ...

Laboratory tests show that palladium(II) complexes of amantadine, memantine and rimantadine inhibit SARS-CoV-2 entry and replication in human lung-derived cells, ...

A patient with relapsed FLT3-mutated acute myeloid leukemia achieved a durable complete remission exceeding five years after switching to gilteritinib.

A narrative review argues that MEK inhibitors have transformed treatment of NF1-associated plexiform neurofibromas, but predominantly partial responses, toxicity, and ...

A longitudinal single-cell study of ER-positive breast cancer links strong estrogen receptor signaling, ER-linked enhancer activity and expanding T cell ...

A scientific review published in Cancer Cell International highlights ATG5 as a context-dependent molecular switch driving therapy resistance and survival ...

New research shows that the long non-coding RNA LINC00332 promotes epithelial-mesenchymal transition, cell migration, and paclitaxel resistance in colorectal cancer ...

A narrative review links an imbalance between kynurenic acid and quinolinic acid in the kynurenine pathway to seizures, drug resistance ...

A new review explains how dapsone remains central to leprosy treatment while its metabolism drives anemia, methemoglobinemia and hypersensitivity risks.

A preclinical study reports that the Notch ligand DLL1 activates an Nrf2/GPX4 antioxidant axis that suppresses ferroptosis and weakens cisplatin's ...

A single-protein synthetic organelle called the recordanelle preserves transient RNA expression records in human cells for at least five days, ...

A new review in Cell Division details how colorectal cancer cells form their own blood-supply channels through vasculogenic mimicry, a ...

A new review examines how plant-derived compounds such as polyphenols, flavonoids, alkaloids and isothiocyanates may target the breast cancer stem ...

Researchers in Cameroon built and tested a machine learning model that predicts antiretroviral resistance from routine clinical data, with XGBoost ...

A new review proposes that the constantly shifting shapes of proteins, not just genetic mutations, drive rapid and reversible drug ...

A phase 3 trial of the pan-RAS inhibitor daraxonrasib doubled median overall survival in previously treated metastatic pancreatic cancer, prompting ...