Tag: drug resistance

Scientists engineered an HVEM-derived peptide that blocked about sixty percent of HSV-1 infection in cell tests without toxicity.

A study of 335 Mycobacterium tuberculosis isolates in China found a pretomanid 99th percentile MIC of 0.25 mg/L in 7H9 ...

A new bibliometric and pharmacological review of 423 Scopus-indexed publications maps four decades of anticancer quinazoline research, revealing a 2018 ...

A new review maps how the four HSP90 chaperone isoforms play distinct roles in lung cancer progression and drug resistance, ...

A new open-access review in Cancer Nanotechnology surveys how nanomaterials could improve colorectal cancer diagnosis, targeted therapy, and personalized theranostics.

A new small molecule strategy activates a stress-responsive E3 ligase to degrade multiple disease-causing proteins at once, restoring mitochondrial function ...

High CD84 expression correlates with venetoclax resistance in AML, and targeting the CD84-SESN2 pathway sensitized leukemia cells to the drug ...

A new review in Cellular Oncology argues that treatment resistance in cancer often stems from selection and remodeling of pre-existing ...

A new review maps how protein arginine methyltransferases both cooperate and antagonize one another in tumors, arguing that multi-target and ...

A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting ...

A methylation mark on translation factor eEF1A selectively speeds decoding of rare, wobble-weak codons, boosting KRAS production and driving resistance ...

Preclinical experiments show that depriving ovarian cancer cells of cyst(e)ine, or blocking its metabolism with drugs, enhances their responsiveness to ...

A new review maps how 3D bone marrow models, from spheroids to bioprinted and organ-on-chip systems, are being used to ...

A published case report describes an 8-year-old boy with multirefractory advanced systemic mastocytosis and mast cell leukemia in whom a ...

A new cell-line study reports that silencing HIF-1α with siRNA synergizes with erlotinib to suppress proliferation, invasion and glycolysis in ...

A new review summarizes how the amino acid transporter SLC7A5 drives tumor metabolic reprogramming and where targeted therapies against it ...

A new review synthesizes the clinical evidence, toxicity profiles and resistance mechanisms behind six FDA-approved antibody-drug conjugates for blood cancers.

A new review outlines translational frameworks for using targeted protein degradation to eliminate the proteins that drive acquired resistance in ...

A new study reports that the kinase CK2α regulates P-glycoprotein expression in macrophages through two signaling pathways, and that combining ...

A hydroxylated chalcone derivative called UR-2 suppressed the growth of CD133-positive lung cancer organoids by lowering Thioredoxin-2 expression and triggering ...