Biomedical researchers have developed scaffold-free self-assembled cell ring organoids that achieve superior tumor uniformity and engraftment rates in preclinical osteosarcoma ...
Endosialin-positive fibroblasts and pericytes drive colorectal cancer angiogenesis through NF-κB and HIF-1α signaling that boosts VEGFA secretion, and an anti-endosialin ...
Researchers report that stromal APOL4 marks a distinct cancer-associated fibroblast state whose loss confers carboplatin resistance in ovarian cancer co-cultures ...
Cancer-associated fibroblasts deliver blood-borne cholesterol to pancreatic cancer cells and suppress T cell function through ANO6-dependent trogocytosis, a contact-based membrane ...
A Cell & Bioscience study links compartment-specific AKAP12 promoter methylation to opposing epithelial and stromal programs in colorectal cancer and ...
A new perspective argues that antigen-presenting fibroblasts in gastrointestinal tumors are reversible states whose immune role depends on unmeasured co-stimulatory ...
A multi-platform pan-cancer analysis finds PTPN3 shows cancer-type-dependent differences in expression, survival associations, genomic alterations, phosphorylation and stromal correlations.
Bone marrow stromal cells drive interleukin-6-mediated metabolic reprogramming and bortezomib resistance in multiple myeloma, a new open-access study reports.
A new review compiles evidence that curcumin, green tea polyphenols, quercetin, and related food-derived compounds can remodel the breast cancer ...
A new review details how metabolically reprogrammed cancer-associated fibroblasts build immune-excluded and immunosuppressive tumor niches that undermine checkpoint blockade, and ...
Sustained blood CXCL1 elevation tracked attenuated Salmonella colonization in four preclinical tumor models.
Researchers identified PLPP4 as a functional marker of an ECM-enriched cancer-associated fibroblast subset that promotes tumor growth and metastasis via ...
A new study identifies the CXCL1/8-CXCR1/2 chemokine axis as a driver of the inflammatory tumor microenvironment and matrix remodeling in ...
A new review finds that while cancer-associated fibroblasts clearly promote tumor growth and suppress natural killer cell activity in endometrial ...
In preclinical castration-resistant prostate cancer models, combining B7-H3 blockade with the MEK inhibitor trametinib overcame compensatory immune suppression and structural ...
A planned Dutch multicenter trial will test whether F-FAPI PET-CT can locate primary tumors in 50 adults with cancer of ...
KIT-led researchers show that inactivating the CD44 molecule reprograms tumor-promoting fibroblasts in pancreatic cancer, reducing fibrosis and immunosuppression and shrinking ...
A multi-omics study combining genomics and spatial transcriptomics finds that BRCA-mutated high-grade serous ovarian cancers show stronger interferon and inflammatory ...
A seven-cohort single-cell atlas links early-onset colorectal cancer to coordinated epithelial, stromal and NOTCH-associated signaling changes.
A 2026 review finds that miR-142-3p generally suppresses tumor-cell growth and improves drug response inside cancer cells, while its extracellular-vesicle ...
