Host Cell Type Shapes Toxoplasma Survival and Epigenetic Profiles
A new study reveals that the host cell type significantly influences the epigenetic and transcriptomic profiles of Toxoplasma gondii, with ...
Tag: Astrocytes
Mouse Study Maps Neuroimmune Crosstalk Between Periodontitis and Alzheimer’s Disease
A single-cell transcriptomic study in mice reveals how periodontal inflammation exacerbates neuroinflammatory signaling and alters glial cholesterol pathways in early ...
Novel PPP1R3F Genetic Mutation Linked to Rare X-Linked Neurodevelopmental Disorder
A clinical report details a novel hemizygous nonsense variant in the PPP1R3F gene identified in a young boy, expanding the ...
Astrocyte Glutamate Uptake Shapes Fear Memory Expression and Reconsolidation in Male Rats
Blocking the astrocytic glutamate transporter GLT-1 in the rat hippocampus spares fear memory formation but disrupts its expression and reconsolidation ...
Maternal immune activation primes adult offspring for insult-dependent Parkinsonian vulnerability in male mice
Maternal immune activation primes adult male mice for insult-dependent vulnerability to Parkinson's disease-related injury.
Astrocytic PDE5 Impairs Mitochondrial Transfer to Neurons During Ischemic Stroke
A study in mouse and cell models reveals that astrocytic phosphodiesterase 5 disrupts bidirectional mitochondrial transfer and biogenesis between astrocytes ...
How Glial Cells Determine Whether Parkinson’s Aggregates Clear or Propagate
A review reveals how microglia and astrocytes act as metabolic checkpoints, dictating whether Parkinson's disease alpha-synuclein aggregates are degraded or ...
Astrocytic Cilia Receptor Drives Amyloid Beta Accumulation and Brain Cell Stress
Researchers have discovered that the ciliary p75 neurotrophin receptor mediates amyloid beta accumulation and oxidative stress in human hippocampal astrocytes.
Brain-derived vesicle profiling opens non-invasive window on Alzheimer’s in Down syndrome
Ultrasensitive profiling of neuron- and astrocyte-derived vesicles from plasma reveals stage-linked protein signatures of neurodegeneration, inflammation and vascular stress across ...
Tetraploid Astrocytes Emerge as Potential Players in Drug-Resistant Temporal Lobe Epilepsy
Tetraploid astrocytes with metabolic and transport markers are significantly increased in the cortex of drug-resistant temporal lobe epilepsy patients compared ...
Repeated Histamine Exposure Shows Lasting Glial Changes and Attenuated Dopaminergic Deficits in Mice
Repeated peripheral histamine injections in mice were associated with persistent, region-specific glial morphometric remodelling and attenuated behavioural and dopaminergic deficits ...
Histone Marks May Hold Alzheimer’s Inflammation in a Persistent State
A new review proposes that histone post-translational modifications sustain neuroinflammation in Alzheimer's disease by encoding pathological immune memory in chromatin.
Trauma-associated microglia drive chronic inflammation after brain injury
Researchers identified trauma-associated microglia that persist chronically after mouse traumatic brain injury and drive exaggerated inflammatory responses and tissue damage.
Lactate Receptor HCAR1 Emerges as a Brain-Wide Tuner of Neuronal Firing
A new mini review details how the lactate receptor HCAR1 modulates neuronal firing across the brain through region-specific ion channel ...
FLASH radiotherapy spares healthy astrocytes while stressing glioma cells
A new Cell Death Discovery study shows FLASH radiotherapy preserves mitochondrial function in healthy astrocytes while driving sustained redox and ...
Astrocytes Emerge as Unexpected Players in Rare Epileptic Disorder CDKL5
Patient-derived astrocytes and human brain slice models reveal water-transport, immune and cytoskeletal abnormalities linked to CDKL5 loss.
Astrocytes may drive chronic traumatic encephalopathy, scoping review finds
A PRISMA-guided scoping review of 40 studies argues that astrocytes act as early, active contributors to chronic traumatic encephalopathy rather ...
CSF GFAP Rises Sharply With Age, New Reference Limits Show
A cross-sectional study of 325 screened Danish biobank participants establishes age-specific upper reference limits for Simoa-measured CSF GFAP, which rise ...
Astrocytes May Link Gut Inflammation in IBD to Depression, Review Suggests
A new review proposes that reactive astrocytes with A1-like features may connect intestinal inflammation in IBD to comorbid depression through ...
Blood Cholesterol Marker Flags Brain Injury Risk in Growth-Restricted Infants
A blood-based cholesterol metabolite, 24S-hydroxycholesterol, shows reduced levels in IUGR infants and predicts neurodevelopmental risk in new mouse and clinical ...
