Silent Synapses Wake Up: How Dormant Brain Connections Could Reshape Treatment of Disease
A sweeping review reveals how dormant silent synapses are activated through coordinated molecular machinery, and how their failure or overactivation ...
Tag: Astrocytes
Prior Flu Infection Reshapes Brain Inflammation and Behavior in Alzheimer’s Mice
A new mouse study shows that a prior H1N1pdm influenza infection reshapes social, affective, and memory behavior and intensifies neuroinflammation ...
How Metabolic Syndrome May Prime the Brain’s Immune Cells and Weaken Its Brakes Against Seizures
A new hypothesis-driven framework proposes that metabolic syndrome may prime the brain's immune cells through trained-immunity-like mechanisms and weaken parvalbumin ...
A Hidden Brain Enzyme Emerges as the Secret Weapon Against Memory Decline in Aging
Scientists have discovered that an aging-induced secreted phospholipase called PLA2G2F acts as a neuron-derived signal that protects synapses, calms inflammatory ...
The Silent Interval: Hidden Brain Remodeling Precedes the Return of Seizures
A time-resolved study of CYFIP2 Arg87Cys mice reveals that the seizure-free interval in West syndrome is a period of active ...
Intranasal Herpes Virus Remodels Brain Immune Cells in a Region-Specific Pattern
A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...
A Few Neurons Overexpressing C4 Remodel the Whole Cortical Neighborhood
Overexpressing the schizophrenia-linked complement gene C4 in just two percent of mouse cortical neurons triggers widespread transcriptional, lipid-droplet, and stress ...
Master Switch Discovered That Decides How Adult Spinal Cord Stem Cells Choose Their Fate
New research reveals that the Hippo pathway effector YAP1 acts as a master switch controlling whether adult spinal cord stem ...
Aging Brains Respond Differently in Males and Females, Mouse Study Reveals
A new study in accelerated-aging mice shows that a neurogenesis-boosting compound rescues memory and hippocampal plasticity in males but not ...
Liver and Brain Drive Separate Symptoms in Rare Inherited Epilepsy, Mouse Study Finds
A Johns Hopkins mouse study shows that liver dysfunction drives seizures while astrocyte defects in the brain drive psychiatric symptoms ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
Astrocytes Drive the Mitochondrial Traffic Jams Behind a Common Form of ALS
New research shows that astrocytes carrying the C9ORF72 mutation disrupt mitochondrial transport in motor neurons through a contact-dependent bioenergetic mechanism ...
Astrocyte Redox Switch Linked to Synapse Damage in Multiple Sclerosis
A new single-cell and animal study links SLC7A11-high astrocyte states to antioxidant failure and synaptic remodeling in multiple sclerosis, pointing ...
Human GLUD2 Gene Variant Worsens Parkinson’s Disease by Igniting an Astrocyte–Microglia Complement Cascade
A human-specific GLUD2 gene variant worsens Parkinson's disease pathology in mice by driving complement C3 signaling from astrocytes to microglia, ...
Silent Brain Attack: Common Autoimmune Dementia Mimic Caught in Largest Study Yet
A large Japanese cohort study finds that 41% of patients with autoimmune GFAP astrocytopathy develop cognitive impairment, with older age ...
APOE2 Allele Switch Enhances Alzheimer’s Outcomes in Mice
In a groundbreaking advancement for Alzheimer’s disease research, scientists have demonstrated that switching the APOE4 gene variant to APOE2 specifically ...
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