Tag: Astrocytes

A 2026 review proposes that reactive astrocytes in hypothalamic and brainstem circuits may contribute to obesity-associated hypertension through glutamate disruption, ...

A controlled mouse study found that APLNR was associated with region- and phase-dependent astrocytic responses during cuprizone-induced demyelination and partial ...

Human postmortem tissue, cultured cells and mouse experiments implicated abnormal ABCA1-dependent cholesterol trafficking in Parkinson’s-related neurodegeneration.

A new review proposes that age-related remodeling of the sugar layer lining brain blood vessels could converge with galectin-3 inflammatory ...

Brazilian researchers found that ellagic acid, a polyphenol from pomegranates and berries, reduced oxidative stress and selectively rebalanced inflammatory signalling ...

A new Nature Cancer study shows that stroke remodels the brain's tumor microenvironment, creating tumor-associated astrocytes and macrophages that drive ...

Stanford researchers used a CRISPR screen in expanded blood stem cells to identify Elp1 as an essential regulator of myeloid ...

A comprehensive review maps how MSC-derived extracellular vesicles modulate the inflammatory microenvironment after spinal cord injury across acute, subacute, and ...

Researchers have demonstrated for the first time in human brain tissue that blocking glutamate transporters elicits a sustained NMDA receptor-dependent ...

New research shows that Caveolin-1, the core protein of mechanosensitive caveolae, is concentrated in optic nerve head astrocytes and rises ...

New research shows that the Parkinson's-linked gene ATP13A2 keeps astrocytic mitochondria in balance, and that its loss triggers excessive mitochondrial ...

A new review in Results in Chemistry details how programmable DNA nanobiosensors combined with artificial intelligence could enable early detection ...

A sweeping review reveals how dormant silent synapses are activated through coordinated molecular machinery, and how their failure or overactivation ...

A new mouse study shows that a prior H1N1pdm influenza infection reshapes social, affective, and memory behavior and intensifies neuroinflammation ...

A new hypothesis-driven framework proposes that metabolic syndrome may prime the brain's immune cells through trained-immunity-like mechanisms and weaken parvalbumin ...

Scientists have discovered that an aging-induced secreted phospholipase called PLA2G2F acts as a neuron-derived signal that protects synapses, calms inflammatory ...

A time-resolved study of CYFIP2 Arg87Cys mice reveals that the seizure-free interval in West syndrome is a period of active ...

A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...

Overexpressing the schizophrenia-linked complement gene C4 in just two percent of mouse cortical neurons triggers widespread transcriptional, lipid-droplet, and stress ...

New research reveals that the Hippo pathway effector YAP1 acts as a master switch controlling whether adult spinal cord stem ...