Biology
New Genomic Method Blends Sequence and Array Data Without Imputation
A new generalized single step method combines any number of hierarchical genomic datasets with pedigree, avoiding imputation and modestly improving...
Bone Clues Fail to Reveal Neoteny in Salamanders and an Ancient Relative
A new study finds no shared pattern in bone histology, microanatomy or life history traits that distinguishes neotenic salamanders from...
Research report: Whole-genome sequencing of CRFK and PG-4 cells to infer the phenotype of the original donor cats
Whole-genome sequencing of the CRFK and PG-4 feline cell lines has allowed researchers to infer that one donor cat had...
Traditional Chinese Medicine Formula Kangxianling Shows Anti-Fibrosis Effects in Rats by Suppressing Ferroptosis
A preclinical study reports that Kangxianling Decoction reduced renal fibrosis in a rat model by suppressing ferroptosis through the p53/GPX4...
CRISPR-Edited Microalgae Boost Carotenoids but Hit Hard Limits on Carbon Capture
A new review finds CRISPR engineering can sharply raise carotenoid yields in microalgae, yet these gains mostly redistribute carbon rather...
Most Norwegian vets start diabetic dogs on insulin, but euthanasia risk remains high
A survey of 125 Norwegian veterinarians found that about 72 percent of diagnosed diabetic dogs are started on insulin, with...
Ash leaf microbiomes share a core bacterial community shaped by climate and site
Across 12 forest sites in Germany, the bacterial communities living on the leaves of European ash trees share a small...
GNAZ Slows Lung Cancer Growth by Triggering KIF11 Destruction and Boosts Osimertinib Response
New research in Cell & Bioscience shows that the G-protein subunit GNAZ suppresses lung adenocarcinoma by promoting HUWE1-mediated degradation of...
SWI/SNF Chromatin Complex Gene Expression Mapped Across 33 Cancer Types
A pan-cancer analysis of about 11,000 TCGA samples maps the expression of all 29 SWI/SNF chromatin remodeling genes across 33...
CD4+ Cytotoxic T Cells Emerge as Double-Edged Effectors in Health and Disease
A new review summarizes how CD4+ cytotoxic T cells act as both protective and pathological effectors, and why targeting them...
Who talks about wildfire adaptation? New study maps the western US conversation
An analysis of press releases, news, and social media from September 2022 to February 2024 finds prescribed fire dominates western...
Low CEBPD Expression Tied to Poor Breast Cancer Survival, Study Finds
Researchers report that the adipogenesis-related gene CEBPD is downregulated in breast tumors, serves as an independent prognostic indicator of survival,...
WHO’s Collaboratory Bets on Shared Tools and Trust to Speed Epidemic Intelligence
A WHO Innovation Forum session reported in BMC Proceedings examined how the Collaboratory's communities of practice, the grEPI parameter repository,...
New AI tool annotates single-cell data with far fewer labels
A new dual-view machine learning framework called scTrans-SVD achieved a mean Macro-F1 of 0.8820 across 13 public single-cell transcriptomic datasets...
SLC7A5 emerges as a central player in cancer amino acid metabolism
A new review summarizes how the amino acid transporter SLC7A5 drives tumor metabolic reprogramming and where targeted therapies against it...
Methyltransferase SMYD2 Activates STAT3 to Drive Kidney Scarring After Cisplatin
Researchers report that the methyltransferase SMYD2 activates STAT3 to drive partial EMT and renal fibrosis in cisplatin-induced chronic kidney disease.
Herbal formulas tied to distinct gut microbiota and metabolic shifts in lambs with coccidia
A study of naturally coccidia-positive lambs in China found that two pathogen-guided herbal formulas were associated with distinct fecal microbiota...
First Scandinavian Case of Equine Neuroborreliosis Confirmed by Spinal Fluid PCR in a Mare
An 11-year-old Norwegian mare with weight loss and ataxia became the first documented equine neuroborreliosis case in Scandinavia after Borrelia...
Brazil’s Fires Split Along Cerrado–Amazon Divide, Four Decades of Data Show
A 40-year analysis of MapBiomas burned-area centroids shows that fires in natural vegetation and anthropogenic land use in Brazil remain...
Gut Microbiota Imbalance Tied to Larval Health in Black Soldier Fly Pig Manure Recycling
A multi-omics study of one black soldier fly rearing event linked gut bacterial and fungal dysbiosis to larval health divergence...
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