Biology
Improved spike-in normalization reveals how active histone modifications relate to transcription
Chromatin, the molecular packaging system that compacts DNA inside the nucleus, is not merely a passive storage device. By loosening...
ID2 directs cDC1 development by blocking E proteins at versatile Zeb2 enhancer
A new study has uncovered how the immune system locks developing cells into the type 1 classical dendritic cell, or...
PASTA Enables Versatile Tyramide-Oligonucleotide Amplification for Multimodal Spatial Biology
Spatial biology has transformed the way researchers view tissues, revealing that cells are defined not only by their molecular identities...
Scientists characterize genetic variants across the human intrinsically disordered proteome
Variant effect prediction has entered a new phase, but one of biology’s largest blind spots remains stubbornly difficult to resolve....
New AI Tool Identifies Proinflammatory Peptides Using Phase-Based Descriptors and Self-Attention
Inflammation is one of the body’s most powerful protective responses, but when it becomes excessive or misdirected, it can contribute...
Scientists Review Mathematical Models of Ephaptic Coupling Between Neurons
Ephaptic coupling, a form of neuron-to-neuron communication that operates without conventional synapses, is moving from the margins of neuroscience toward...
Chronic Nitrogen Deposition Reshapes Diazotrophs, Suppresses Fixation, Rewires Deadwood Fungal Networks
Nitrogen deposition is quietly rewriting the biological life of forests, and a new study suggests that one of the most...
NSF renews Quantum Leap institute with $37.5 million for quantum biology sensing
The U.S. National Science Foundation has renewed the Quantum Leap Challenge Institute for Quantum Sensing for Biophysics and Bioengineering, known...
Hypercontractile embryos from older female mice experience implantation failure
A hidden mechanical failure inside the earliest stages of life may help explain why fertility declines so sharply as females...
European summit plant communities show widespread thermophilization, weakly linked to climate warming
Europe’s highest plant communities are getting warmer in character, but not necessarily because the climate above them is warming in...
Scientists design tissue-specific mammalian enhancers that function in mouse embryos
A new study reports a step toward treating mammalian gene regulation as an engineering problem: rather than searching through the...
Disrupted Cellular RNA Balance Drives MDA5 Activation During Viral Infection
For decades, antiviral immunity has been described as a molecular surveillance system built to distinguish the genetic material of invading...
Experts develop consensus approach for spatially aware clustering beyond benchmarking
Spatial biology has created a problem that conventional clustering benchmarks were never designed to solve. In technologies such as spatial...
Scientists Identify Factors Governing Human β2-Adrenergic Receptor–β-Arrestin Complex Assembly
A new study published in Nature Structural & Molecular Biology is clarifying how one of the most important signaling complexes...
Benchmarking ESM2 Across Scales for Predicting Viral Entry Proteins
Viral entry proteins are among the most consequential molecules in infectious disease biology. Positioned at the interface between a virus...
Single-cell RNA sequencing maps gonadal changes during sex reversal in orange-spotted grouper
A single-cell transcriptomic study of the orange-spotted grouper, Epinephelus coioides, is offering an unprecedented view of how a fish gonad...
Genomic Study Reveals Diversity, Light-Powered Proteins, and Eight New Aquirufa Species
Freshwater ecosystems are home to an extraordinary fraction of Earth’s microbial diversity, yet many of the bacteria inhabiting rivers, lakes...
Targeting POLG Weakens Breast Cancer Stemness by Disrupting Mitochondrial Function
A new study is drawing attention to a possible metabolic vulnerability in breast cancer stem cells: the mitochondrial DNA maintenance...
Balanced mRNA and ribosome levels govern growth in eukaryotic cells
A new study in budding yeast suggests that one of biology’s most fundamental processes—cell growth—may be governed by a remarkably...
Non-native plants’ mycorrhizal strategies shift across biomes and disturbance levels
A global study has challenged one of ecology’s most persistent assumptions about invasive plants: that their success is consistently powered...