Biology
TUDCA restores maturation of aged eggs in vitro by reducing ER stress
A Bile Acid Derivative Could Help Restore the Maturation of Aging Eggs A compound best known for protecting cells from...
UIDDA Unifies Model and Classifier Inputs to Predict Drug-Disease Associations
A new benchmarking framework is challenging a hidden weakness in artificial-intelligence research aimed at discovering which drugs might treat which...
Geochemical Constraints Shaping Sediment Microbiomes in Gypsum Caves Revealed
Beneath the sun-baked landscape of southeastern Spain, an underground microbial world is being shaped by chemistry that changes from one...
JAK2V617F Gold Nanoparticles Suppress IRF7 and TLR9 Activation
Gold Nanoparticles Rewire Inflammatory Signals in Cells Carrying a Cancer-Linked JAK2 Mutation Tiny gold particles carrying genetic targeting molecules have...
Metabolomic and transcriptomic analyses uncover monoterpenoid indole alkaloid biosynthesis in Neolamarckia cadamba
A Medicinal Tree’s Hidden Chemistry Comes Into Focus as Scientists Map the Genes Behind Its Alkaloids A tropical tree revered...
New patches detect volatile metabolites linked to Burkholderia cepacia
A simple chemical “sniff test” built from tiny coated patches could help researchers detect the lung-associated pathogen Burkholderia cepacia by...
Study uncovers possible role of AINTEGUMENTA-LIKE 7 in Arabidopsis clubroot resistance
A Plant Gene With a Surprising Double Life Could Help Protect Crops From Clubroot A small flowering plant has revealed...
How CsgD Regulates Biofilm Formation and Quorum Sensing in Salmonella Typhimurium
A Master Switch in Salmonella May Link Sticky Biofilms to Bacterial “Social” Signals A gene regulator best known for helping...
Three New Chinese Neritidae Mitochondrial Genomes Clarify Their Evolutionary Relationships
A trio of tiny snails collected along China’s coasts and waterways has provided scientists with new genetic clues to one...
Seasonal Shifts in Shitalakshya River Microbes and Antibiotic Resistance Revealed by Metagenomics
Bangladesh River’s Dry-Season Crisis Is Selecting for Microbes Built to Survive Pollution A river supplying drinking water to millions of...
Unresectable Gallbladder Cancer Develops Rare Spontaneous Cholecystocutaneous Fistula, Case Report Finds
Gallbladder cancer has produced an exceptionally rare and unsettling complication in a 65-year-old man: a spontaneous tunnel from the diseased...
Study Reveals Shared Biological Mechanisms Linking Muscle Loss and Osteoporosis
What would you like me to do with this manuscript section? I can, for example: Polish the English for grammar,...
Scn1b/Gsdmd knockdown promotes M2-like macrophages, modulating inflammation and fibrosis in rat ARDS
Acute respiratory distress syndrome (ARDS) remains one of the most difficult forms of critical lung injury to treat. The syndrome...
Plant Enzymes Enable Efficient Production of N-(Hydroxycinnamoyl)tyramines with In Situ Precipitation
Scientists have developed a new fermentation-based method for producing hydroxycinnamoyltyramines, a family of plant-derived phenolic compounds that has attracted growing...
FOXP3, Key Regulatory T Cell Activator, Found Across Amphibians
Amphibians carry a gene that may be central to one of the immune system’s most important balancing acts, according to...
MSR Gene Discovery in Four Wheat Species Reveals TaMSRB5 Enhances Copper Tolerance
Methionine is often described as one of the quiet workhorses of biology. It helps initiate protein synthesis, supports cellular metabolism...
Human long noncoding RNA localization is isoform-specific, obscured by gene-level analysis
Long non-coding RNAs have long been treated as if each gene produces a single molecular identity: one RNA, one cellular...
T Cells Mount Powerful Defense Against Zika Virus
Zika virus vaccines have long faced a difficult immunological problem: the antibodies they generate may protect against infection, but they...
Zika Vaccine With E Protein Fusion-Loop Mutations Protects Through CD8+ T Cells
Zika virus vaccine research has taken a decisive turn toward understanding not only whether vaccination prevents infection, but also which...
DREAMS Maps Spatial DNA and RNA Modification Landscapes
A new method reported in Nature Cell Biology is offering scientists an unusually detailed view of how chemical modifications are...