Early Spinal Muscle Loss Emerges as Hidden Driver of Muscular Dystrophy
MRI studies of patients and dysferlinopathic mice reveal early fatty degeneration of spinal muscles driven by adipogenic progenitors, with GSK3 ...
Tag: Wnt Signaling
Carmn Keeps Exocrine Gland Stem Cells Primed for Wnt Signaling
A new EMBO Reports study shows that the lncRNA Carmn sustains basal stemness across mammary, salivary, and lacrimal glands by ...
Natural Saponin Esculentoside A Curbs Liver Cancer Growth by Stabilizing RORB Protein
A new preclinical study reports that the plant-derived saponin esculentoside A suppresses hepatocellular carcinoma growth and stemness in cells and ...
How Hippo, Wnt, NRG1 and Notch pathways could unlock heart regeneration
A new review synthesizes the signaling pathways, extracellular matrix cues, metabolic switches and transcription factors that govern cardiomyocyte proliferation and ...
Moth Wing Shape Altered in Lab First, Backing Butterfly Cookie-Cutter Idea
A seven-year experiment has for the first time altered the shape of moth wings, supporting the idea that moths and ...
Nuclear CK1α joins the WNT transcription machine to drive tumor-initiating cells
Nuclear L-insert-containing CK1α isoforms act as positive components of the β-catenin/TCF complex, while pharmacological CK1α activation with SSTC3 depletes WNT-driven ...
Blocking Two Opposing Signals Steers Repair Cells Back to Rebuilding Myelin in Mice
In a mouse model of demyelination, OPCs shift toward an astrocyte-like state through opposing BMP and Wnt signaling, and blocking ...
Alx4 keeps its limb-building role even as its expression shifts across amniotes
A new study finds that the Alx4 gene shows divergent limb bud expression in chicken and mouse, yet its protein ...
Wnt Signaling and CDX2/T/TBX6 Axis Drive Human Urine Cell Reprogramming into Presomitic Mesoderm
A new study maps how Wnt/β-catenin signaling and the Dot1L inhibitor EPZ5676 coordinate the reprogramming of human urine-derived cells into ...
PYGO2 and MAML1 expression linked to early-stage papillary thyroid cancer
A study of sixty papillary thyroid carcinoma tumors found that PYGO2 and MAML1 expression levels were significantly higher in early-stage ...
Culture Medium Rewrites Drug Sensitivity in Patient-Derived Tumor Organoids
A new study shows that the choice between Wnt-based and OncoPro culture medium reshapes the transcriptional state and drug sensitivity ...
Review proposes SFRP4–integrin interaction may restrain tumor angiogenesis
A 2026 review proposes that SFRP4 may inhibit tumor angiogenesis through integrin-linked disruption of Wnt–β-catenin signaling, but the supplied evidence ...
LF3 restores 5-FU sensitivity in resistant colorectal cancer cell model
LF3 inhibited Wnt/β-catenin signaling and restored 5-fluorouracil sensitivity in a preclinical HCT-116 cell model of long-term chemotherapy resistance.
Novel CTNNB1 missense variant identified in child with spastic diplegia and visual defects
A 7-year-old Iranian boy with a previously unreported CTNNB1 missense variant showed developmental delay, spastic diplegia, microcephaly, behavioral problems and ...
Faulty Connexin 43 Gene Reveals Hidden Signaling Switch Behind Rare Bone Disorder
A new study shows that GJA1 mutations in oculodentodigital dysplasia suppress Wnt/c-MYC signaling, driving a paradoxical inflammatory imbalance and excessive ...
Giant River Prawn Embryos Reveal a Dramatic Genetic Handover From Mother to Embryo
A new transcriptomic study maps eight embryonic stages of the giant river prawn, revealing a massive early genetic shift consistent ...
Single-Cell Map Reveals How Embryonic Ducts Build or Abandon the Female Reproductive Tract
Single-cell transcriptomics in chicken embryos reveals the molecular programs that build the female Müllerian duct and drive its regression, identifying ...
β-Catenin Inhibitors Show Potent Activity Against Double-Mutant Endometrial Cancer in Preclinical Study
A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...
Ancient Jumping Genes Help Explain How DNA Variants Shape the Human Cortex
A massively parallel reporter assay of 9,092 cortical-structure-associated variants reveals that Alu retrotransposons, Wnt signaling and transcription factor expression jointly ...
Gliding Mammals Evolved the Same Skill Through Different Genetic Routes
A genomic comparison of three independently evolved gliding mammal lineages shows that different regulatory DNA regions can converge on similar ...
