Wnt Pathway Dysfunction Linked to Down Syndrome Cell Stress
A study in BMC Molecular and Cell Biology finds that Wnt/β-catenin pathway suppression in Down syndrome amniocytes is linked to ...
Tag: Wnt Signaling
Superficial Fascia Telocytes Exhibit Layer-Adapted States and Interfacial Communication Potential
Researchers identified layer-adapted states of Cd34+Pdgfra+ telocytes across the ventral body wall continuum, highlighting their potential role in interfacial intercellular ...
UBE2K-FBXO11 Complex Activates Wnt Signaling by Stabilizing Beta-Catenin via Polyubiquitination
A genome-wide CRISPR screen reveals that the UBE2K-FBXO11 complex stabilizes beta-catenin through K63-linked polyubiquitination to promote Wnt signaling and cancer ...
RAS Mutations Reshape Chromatin Architecture and WNT Signaling in Colorectal Cancer
Researchers utilizing isogenic colorectal cancer models demonstrated that KRAS and BRAF mutations alter chromatin accessibility and transcriptional programs with convergent ...
AGS Compounds Boost TERT and Reduce Amyloid Plaques in Alzheimer’s Mice
Daily subcutaneous administration of synthetic tri-aryl AGS compounds elevated protective telomerase reverse transcriptase, reduced amyloid beta plaque burden, and improved ...
WNK Kinases Regulate RNF43 Cell Surface Levels to Modulate WNT Signaling
Researchers have discovered that WNK family kinases regulate the cell surface abundance and ubiquitination of the E3 ubiquitin ligase RNF43, ...
Elastin peptides in silk hydrogels aid cranial bone repair
A new study reveals that elastin peptides in silk fibroin hydrogels promote cranial bone regeneration by epigenetically regulating the ROCK1/Wnt/β-catenin ...
Manta Ray Fin Splitting Is Initiated by Wnt Pathway Inhibitor DKK1
Researchers have demonstrated that applying the Wnt antagonist DKK1 to little skate embryos arrests apical ectodermal ridge signaling and truncates ...
MicroRNA Out-Seed Variants Linked to Breast Cancer Subtypes in Vietnamese Women
An exploratory case-control study of 100 Vietnamese women identified preliminary associations between three microRNA out-seed variants regulating WNT and NOTCH ...
Sclerostin Protein Linked to Peripheral Bone Loss in Premenopausal Rheumatoid Arthritis
A case-control study reveals that premenopausal women with rheumatoid arthritis exhibit elevated serum sclerostin levels that correlate inversely with peripheral ...
Protein FRZB Restores Bone-Forming Capacity in Periodontal Stem Cells During Inflammation
Researchers have found that overexpressing the protein FRZB restores mitochondrial function and rescues the bone-forming capacity of periodontal ligament stem ...
DKK1 emerges as a multifunctional player in cancer progression
A new review consolidates evidence that the secreted protein DKK1 acts through multiple signaling routes and is associated with poor ...
LINC00332 drives colorectal cancer cell migration and paclitaxel resistance
New research shows that the long non-coding RNA LINC00332 promotes epithelial-mesenchymal transition, cell migration, and paclitaxel resistance in colorectal cancer ...
Scientists design first selective TNKS2 inhibitor to shut down WNT signaling in 8p-deleted tumors
Researchers developed the first TNKS2-selective inhibitor, TDI-012804, which suppresses WNT signaling in cancer cells lacking TNKS1 through chromosome 8p deletions ...
Epilepsy-Linked RAPGEF5 Variant Shifts Protein Out of the Nucleus in Belgian Shepherds
A 3-base-pair insertion in the RAPGEF5 gene, tied to idiopathic epilepsy risk in Belgian shepherds, pushes the protein predominantly into ...
Genome study reveals shared genetic roots of fibrotic diseases
A genome-wide meta-analysis across five cohorts identifies 654 genetic associations and shared pathways linking fibrotic diseases.
Circulating miRNAs may flag who develops epilepsy after a first seizure
A small exploratory study found 15 cell-free miRNAs in plasma that differed between patients whose first unprovoked seizure remained isolated ...
Loss of Epigenetic Regulator ASH2L Causes Cleft Palate in Mice
Deleting the epigenetic regulator Ash2l from developing palatal mesenchyme collapses the H3K4me3 histone mark, silences Wnt5b, and produces complete cleft ...
How the Nose Rebuilds Itself: Stem Cells and New Tools Reveal Olfactory Repair
A new review summarizes how basal stem cells sustain lifelong olfactory epithelium renewal and how single-cell and organoid technologies are ...
Cadherin Gene Overexpression Linked to WNT Signaling in Nasopharyngeal Carcinoma Cells
A new Cell Division study reports that cadherin genes CDH1, CDH2, and CDH3 are upregulated in nasopharyngeal carcinoma cell lines ...
