Tag: tumor microenvironment

A review of 86 cellular, animal and clinical studies reports multiple antitumor mechanisms for ginsenosides in liver-cancer models, while noting ...

A collagen-targeted protein MRI contrast agent developed at Georgia State University detected invasive lung tumors and multi-organ metastases as small ...

A computational and laboratory study found that reducing HLTF diminished prostate cancer cell proliferation and suggested regulation of ZBP1-PANoptosome assembly ...

A multi-omics study linked ELF1 to B-cell states and breast-cancer prognosis, with cohort associations and laboratory experiments supporting further biological ...

A combined bulk and single-cell transcriptomic study identifies FLT3 and AIM2 among immune-associated genes in prostate cancer, while cell-line knockdown ...

A new review details how the immune checkpoint ligand PD-L1 doubles as a tumor-intrinsic driver of invasion through a reciprocal ...

Pancreatic ductal adenocarcinoma remains one of medicine's most unforgiving diagnoses. Despite decades of progress in surgical technique and chemotherapy, the ...

A 2026 Review argues that osteosarcoma survival and lung spread depend on stage-specific rewiring of extracellular-matrix signaling rather than one ...

An AI-driven single-cell and spatial multi-omics study defines three glioma ecosystem states and shows that a hypoxic myeloid-mesenchymal state independently ...

KIT-led researchers show that inactivating the CD44 molecule reprograms tumor-promoting fibroblasts in pancreatic cancer, reducing fibrosis and immunosuppression and shrinking ...

A multi-cohort re-analysis of melanoma transcriptomes and single-cell immune data links coordinated checkpoint-gene expression to longer overall survival, treatment-related immune ...

A review in Journal of Translational Medicine describes how dysregulated RNA editing suppresses tumor immune recognition and how programmable RNA ...

A study in Journal of Translational Medicine shows that the tumor protein stratifin stabilizes PAK1 and activates MYC-driven NECTIN2 expression, ...

A seven-cohort single-cell atlas links early-onset colorectal cancer to coordinated epithelial, stromal and NOTCH-associated signaling changes.

A 2026 review finds that miR-142-3p generally suppresses tumor-cell growth and improves drug response inside cancer cells, while its extracellular-vesicle ...

Laboratory experiments and simulations indicate that disordered substrates can roughen tumor-cell boundaries and promote detachment, a mechanism that remains to ...

A narrative review links heat shock proteins to gastric cancer invasiveness, resistance and immune modulation, but finds that most therapeutic ...

A proposed liquid-biopsy strategy combines tumor-associated and organ-associated markers on circulating extracellular vesicles to infer metastatic sites, but it remains ...

A 2026 review finds that TCR-engineered T cells have entered early clinical testing for hepatocellular carcinoma, but safety, antigen heterogeneity ...

A small clinical study linked lipid metabolism and mitochondrial respiration to low CD8-positive T-cell infiltration in esophageal adenocarcinoma using spatial ...