Tag: Therapeutic Target

A new study identifies CHRDL2 as a key mediator linking sarcopenia and MASLD through the suppression of BMP/SMAD signaling, suggesting ...

A new study identifies MTFR2 as a key driver of liver cancer progression by activating the PI3K/AKT signaling pathway, offering ...

A study published in Cellular Oncology reveals that OTUD1 stabilizes SLC7A11 via deubiquitination to suppress ferroptosis and promote lenvatinib resistance ...

A systematic review in Diagnostic Pathology evaluates Cytokeratin 19 expression across 476 human malignant cell lines, highlighting its role in ...

Lab experiments show that HAPLN1 secreted by rheumatoid arthritis synovial fibroblasts pushes macrophages toward a proinflammatory M1 state through PI3K/AKT/NF-κB ...

A new narrative review argues that conflicting CDKN3 findings across cancers reflect incompatible evidence types, not a true molecular paradox.

A systematic review links the SEL1L-HRD1 quality control complex to neurodegeneration, cancer, metabolism and immunity.

New research identifies the SBF2-AS1/miR-149-5p/PHLPP2 axis as a driver of cardiomyocyte injury after acute myocardial infarction in mouse and cell ...

A new study reports that MDM4 promotes glycolysis and proliferation in TP53-mutant oral squamous cell carcinoma by stabilizing the enzyme ...

A new study reports that the cytokine IL-17A drives malignant T-cell proliferation in cutaneous T-cell lymphoma by increasing mitochondrial electron ...

A new review maps how calreticulin and its fragments can both promote and suppress tumors depending on context.

A new study shows that TGF-β-driven PFKM downregulation reroutes glucose toward glycogen storage and promotes invasive, mesenchymal-like behavior in lung ...

A new review proposes that the astrocytic stress-responsive protein NDRG2 coordinates multiple depression-related pathways and may serve as a precise ...

A new study reports that blocking SMYD3 limits uveal melanoma cell proliferation, migration, invasion and tumor growth by regulating the ...

A new study finds that the long noncoding RNA MANCR is elevated in glioblastoma and promotes tumor growth and invasion ...

A new review in Medical Oncology details how the mitochondrial transporter SLC25A39 links glutathione import, iron-sulfur cluster assembly and tumor ...

Duke pathology researchers report that the membrane protein SERINC2 remodels phosphatidylserine to activate AXL signaling and reshape the brain immune ...

University of Oklahoma researchers report that MLKL, a protein best known for its role in necroptotic cell death, promotes obesity-related ...

A preclinical study found that SIRPα signaling inside triple-negative breast cancer cells promoted mitochondrial fission, motility, immune tolerance and brain ...

A 2026 review presents CCT6A as a candidate diagnostic and prognostic biomarker in cancer while highlighting context-dependent mechanisms, absent subunit-specific ...