Preclinical Review Links Natural Compounds to PPARγ in Colitis Models
A 2026 review finds that several natural compounds alter PPARγ-related pathways in cellular and mouse models of ulcerative colitis, but ...
Tag: preclinical research
Fucoidan-coated psoralen nanoparticles show promise in breast-cancer mouse models
A preclinical study found that fucoidan-coated zein nanoparticles increased psoralen uptake in 4T1 breast-cancer cells, prolonged tumor-associated retention in mice, ...
Systematic review of 14 in vitro studies links natural products to apoptosis in salivary gland mucoepidermoid carcinoma
A systematic review of 14 in vitro studies found that natural products showed antiproliferative and proapoptotic activity in human mucoepidermoid ...
Cell assays and molecular modeling assess 1,2,3-thiadiazole derivatives against cancer cell lines
A cell-based and computational study found compound 5g had the highest measured cytotoxic activity in most tested cancer cell lines ...
Bruceine D suppresses osteoclast formation and protects bone in ovariectomized mice
A preclinical cell-and-mouse study found that Bruceine D inhibited osteoclast formation through effects involving STAT3, NF-κB and NFATc1 while improving ...
GB10 shows durable anti-leakage effects in animal eye models
GB10 reduced pathological blood-vessel leakage in monkey and rabbit eye models at lower doses and for longer durations than faricimab, ...
LF3 restores 5-FU sensitivity in resistant colorectal cancer cell model
LF3 inhibited Wnt/β-catenin signaling and restored 5-fluorouracil sensitivity in a preclinical HCT-116 cell model of long-term chemotherapy resistance.
Pentalinonsterol shows dual antileishmanial effects in preclinical evidence
A critical review finds that pentalinonsterol acts against Leishmania in experimental models while also altering several host-cell pathways, but its ...
Combined plant fractions induce mitochondrial dysfunction and apoptosis in yeast
A yeast study found that combined plant fractions induced mitochondrial dysfunction and apoptosis-associated changes, with the strongest effects measured at ...
Singapore’s A*STAR and HistoIndex Join Forces to Speed Fibrosis Drug Development
Singapore's A*STAR has signed a Memorandum of Understanding with AI digital pathology firm HistoIndex to quantitatively evaluate preclinical therapeutic candidates ...
How a Richer Environment Rewires the Brain’s Chemistry: New Review Maps Environmental Enrichment Across Neurotransmitter Systems
The distinction between the well-characterized and poorly-characterized neurotransmitter effects of environmental enrichment deserves closer examination, because it reveals something important ...
Left Brain, Right Brain: Why Rodent Disease Models Overlook Hemispheric Asymmetry
The practical implications of this systematic review extend well beyond academic taxonomy. When researchers pool data from both hemispheres without ...
Diabetes Drug Candidate AdipoRon Emerges as Unexpected Driver of Leukemia Blood Vessel Growth
A new correspondence in Molecular Biology Reports highlights evidence that the adiponectin receptor agonist AdipoRon promotes angiogenesis in B-cell leukemia ...
Honey Shows Protective and Therapeutic Effects Against Pancreatic Cancer in Rat Study
A Turkish research team reports that Quercus pyrenaica honey significantly reduced precancerous pancreatic lesions in rats both when given preventively ...
Self-Learning Controller Keeps Drug Levels on Target in the Living Brain
Researchers have demonstrated an adaptive feedback controller that measures drug concentrations in the living brain in real time, learns each ...
Gene Therapy Slows ALS Onset in Mice Models
In a groundbreaking study, researchers have unveiled a potential breakthrough in the treatment of Amyotrophic Lateral Sclerosis (ALS) through innovative ...
Super productive 3D bioprinter could help speed up drug development
A 3D printer that rapidly produces large batches of custom biological tissues could help make drug development faster and less ...
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