Tag: preclinical research

A new review proposes that total glucosides of paeony may interrupt the gut–liver axis vicious cycle driving cirrhosis, though the ...

A new open-access review maps how mitochondrial transfer and transplantation could treat cardiovascular diseases, from cellular mechanisms to early clinical ...

A new review maps how biomaterials can exploit cholesterol metabolism in cancer while warning that most mechanistic claims remain unproven.

Researchers developed a biodegradable magnetic robot that uses microneedles to deliver biologics to the intestine with delayed onset and sustained ...

Preclinical assays found that NU7441 displaced BRD4 from acetylated chromatin and impaired homologous recombination and non-homologous end joining in ovarian ...

A preclinical Mayo Clinic study found that MAPK inhibitors restored TSHR on anaplastic thyroid cancer cells and improved tumor control ...

An animal study by City of Hope researchers shows that modular CAR T cells can accept engineered adaptors after treatment, ...

A systematic review of 34 murine studies published from 2010 to 2025 finds bacterial lysates show consistent preclinical immunomodulatory effects ...

Eculin and esculetin, coumarins from the traditional medicine Qinpi, simultaneously stimulate bone-forming osteoblasts and suppress bone-resorbing osteoclasts in mice, offering ...

A selective, brain-penetrant CD38 inhibitor raised NAD+ levels in rodent brain, protected dopaminergic neurons from alpha-synuclein toxicity in vitro, and ...

Preclinical experiments identify kurarinol A as a candidate MyD88-targeting compound that suppresses activated hepatic stellate cells, while animal benefits were ...

A 2026 review maps altered glucose, lipid and amino-acid metabolism across four major lung cell populations and identifies promising but ...

Preclinical experiments found that tetrandrine promoted ferroptosis in NSCLC models, enhanced CD8⁺ T-cell effector responses and improved anti-PD-1 tumor suppression ...

A five-aptamer panel reduced tumor-cell viability, proliferation, migration and colony formation in several triple-negative breast cancer cell lines, with variable ...

A patient-derived colon cancer liver-metastasis cell line, CRC-X1, was stably passaged through 59 generations, formed tumors in 60% of mouse ...

A Schistosoma japonicum-derived microRNA reduced liver fibrosis in carbon-tetrachloride-treated mice alongside lower stellate-cell activation, collagen deposition and inflammatory signaling.

Cell-culture and mouse experiments found that low-concentration simvastatin promoted osteogenic activity and endothelial network formation through a process associated with ...

A 2026 editorial synthesizes epidemiological, clinical and preclinical evidence highlighting candidate pharmacological targets for alcohol use disorder while emphasizing that ...

A preclinical Singapore study identified PAI-1 and S100A10 as ascites-associated drivers of peritoneal metastases and found that the PAI-1-targeting nanobody ...

A mini review finds that preclinical evidence links repeated or prolonged sevoflurane exposure during development with neuroinflammation, microglial activation and ...