A narrative review evaluates natural bioactive compounds and biomaterial-based delivery systems designed to prevent post-laminectomy epidural fibrosis, highlighting preclinical efficacy ...
A preclinical study shows that metabolic repair enzyme NAXE maintains HIF1α protein stability and supports hypoxia-driven progression in triple-negative breast ...
A study in mice shows that the rare APOE Christchurch mutation prevents the accumulation of toxic proteins tied to Parkinson's ...
A 23-day bone marrow culture protocol generates roughly 1.5 billion high-purity CD103-positive cDC1 immune cells from a single mouse.
A new review finds that ultrasound-triggered sonodynamic therapy combined with chemotherapy remains an investigational, preclinical approach for lung cancer, with ...
Researchers found that the natural flavonoid isoorientin relieved chemically induced atopic dermatitis in mice by modulating macrophage polarization and AMPK/NLRP3 ...
Preclinical findings in Oncotarget show that adaptive feedback driven by DUSP5 limits the therapeutic efficacy of DUSP4 inhibition in BRAF-mutant ...
An experimental tumor-targeted TGF-β blocker cleared aggressive cancers in mice and stimulated durable immune memory across multiple solid tumor types.
A traditional fermented preparation of Polygonatum rhizome brewed with Shanxi aged vinegar craftsmanship suppressed liver cancer cell growth and shrank ...
Researchers demonstrated that TSPO-targeted PET imaging with DPA-714 selectively maps early inflammatory muscle remodeling downstream of peripheral nerve crush in ...
A literature review evaluates preclinical rodent models of acute kidney injury and chronic kidney disease to support therapeutic discovery.
Researchers have developed a slug-inspired thermoresponsive hydrogel that rapidly solidifies inside the body to seal gastrointestinal fistulas in animal models.
A comparative preclinical investigation revealed that the investigational oral compound povorcitinib selectively inhibits Janus kinase 1 over related family members ...
A new study in Genes & Nutrition shows that short-term caloric restriction partially reprograms immune and microbial networks in mice ...
A new multiscale imaging pipeline reveals the survival and fusion of transplanted human pericytes in regenerating mouse muscle, offering insights ...
A study in Fluids and Barriers of the CNS finds that APPswe/PS1dE9 mice show no major integrative brain clearance deficits ...
A scientific review evaluates the molecular mechanisms, signaling pathways, and preclinical therapeutic potential of the kava chalcone Flavokawain A across ...
A systematic review and meta-analysis finds that electroacupuncture preconditioning is associated with reduced myocardial injury and favorable mitochondria-associated changes in ...
Weill Cornell Medicine has received more than $635,000 in first-year funding from the NIH's stroke and neurology institute to refine ...
A study in Cell Biology and Toxicology shows that a darunavir-analogue precursor enhances tamoxifen response in breast cancer by inducing ...
