Microglial NLRP3 Inhibition Restores Memory After Hemorrhagic Shock in Mice
A mouse study finds that inhibiting the NLRP3 inflammasome specifically in microglia reduces hippocampal neuroinflammation and reverses cognitive deficits after ...
Tag: Neuroinflammation
Retina’s Master Support Cells Take Center Stage in Blinding Disease
A new review argues that Müller glia, the retina's dominant support cells, actively shape retinal disease progression and may offer ...
Plant Compound Ivangustin Pins Neuroinflammation on Covalent Hit at UBE2L3 Cys86
A new study reports that ivangustin, a sesquiterpene lactone from Inula japonica, suppresses microglial NF-κB signaling by covalently modifying cysteine ...
From PTZ to Brain Organoids: How Scientists Choose the Right Epilepsy Model
A new review maps how chemical, electrical, genetic, acquired, and in vitro epilepsy models each capture distinct mechanisms of epileptogenesis, ...
Loss of CD47 Shifts Mouse Hippocampus Toward a Mild Stress-Like State
Single-nucleus RNA sequencing shows that Cd47 loss shifts the mouse hippocampal transcriptome toward a state resembling mild excitotoxic stress.
Research report: Fulminant pancreatic encephalopathy with brain edema and herniation in severe hypertriglyceridemia-induced pancreatitis: a case report
A 23-year-old woman with insulin resistance and severe obesity arrived at an emergency department in Beirut with severe upper abdominal ...
Chitosan Nanoparticles in GelMA Hydrogel Deliver Resveratrol in pH-Responsive Manner In Vitro
An in vitro study reports a chitosan nanoparticle and GelMA hydrogel platform that releases resveratrol faster at acidic pH and ...
When Do Repeated Concussions Stop Being Transient? New Research Topic Weighs In
A new Frontiers in Neurology editorial argues that symptom resolution may mask persistent biological changes after repeated concussions.
Stroke begins years earlier: vascular dysfunction offers a window for prevention
A new review argues that stroke is the endpoint of progressive vascular failure and that translational models can uncover biomarkers ...
New Radiotracer Targets Brain Immune Cells With Unmatched Selectivity
Researchers validated 5-MOP, a tritium-labeled radioligand that binds CSF1R with 9.8 nM affinity and far greater kinase selectivity than the ...
How Metabolic Inflammation and a Wobbling Nervous System May Feed Anxiety
A new narrative review proposes that low-grade metabolic inflammation and autonomic nervous system instability may jointly contribute to anxiety through ...
Plasma microRNA signature identified in treatment-naïve primary progressive multiple sclerosis
An exploratory case-control study identified 24 plasma microRNAs with corrected-significant differences in treatment-naïve primary progressive multiple sclerosis patients.
Probiotics and children’s neurodevelopment research mapped in new bibliometric analysis
A bibliometric analysis of 1,684 Web of Science documents from 1998 to 2026 maps the rapid growth of probiotics and ...
Neuron-derived CCL3 drives neuropathic pain after brachial plexus avulsion in mice
A mouse study finds that the chemokine CCL3, produced by neurons in the spinal dorsal horn, mediates neuropathic pain and ...
Parasite-Driven Brain Changes May Explain Epilepsy in Neurocysticercosis
A narrative mini-review argues that neurocysticercosis-related epilepsy arises from active parasite-host-neuron interactions, not inflammation alone.
Mouse Brain Study Uncovers NDN and IDE as Candidate Fragile X Biomarkers
RNA sequencing of fragile X model mice identified the proteins NDN and IDE as strongly upregulated candidate tissue biomarkers, with ...
Gut Microbes, Immune Signals and the Inflammatory Road to Parkinson’s Disease
A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's ...
Losing cGAS Drives Microglial Decline and Progressive Neurodegeneration in Mice
A new mouse study finds that losing cGAS disrupts microglial homeostasis and drives progressive neurodegeneration from early adulthood.
Cannabidiol shows preclinical promise against Alzheimer’s disease, but key evidence gaps remain
A new review finds cannabidiol consistently reduces neuroinflammation and oxidative stress in Alzheimer's preclinical models, but evidence for amyloid, tau, ...
Psychobiotics and Fermented Foods May Target the Gut-Brain Axis in Alzheimer’s Disease
A new review finds that psychobiotics and fermented foods show neuroprotective effects in animal models of Alzheimer's disease, while clinical ...
