Engineered B. subtilis Sets Record for Invertase Production
Engineered Bacillus subtilis strain WBSS142I4PA achieves record extracellular invertase activity of 568.86 U/mL, facilitating the conversion of soybean raffinose into ...
Tag: Metabolic engineering
Sequential Gene Regulation in Escherichia Coli Drives Complete Synthesis of Plastic Precursor
Researchers engineered an Escherichia coli strain using sequential thermal and chemical regulation to convert 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid with complete ...
Research report: Genetic Engineering Efforts to Generate Chlamydomonas Strains for Large‐Scale Biomolecule Production
Synthetic biology advancements and multi-trait genome engineering are transforming the model microalga Chlamydomonas reinhardtii into a versatile photosynthetic biomanufacturing platform ...
Engineered Bacteria Produce L-Threonine From Acetate Using pH-Controlled Cultivation
Researchers engineered Corynebacterium glutamicum to produce L-threonine from acetate using automated pH-controlled feeding in bioreactors.
Yeast Tolerance to Ferulic Acid Mapped by Transcriptomics and Metabolic Modeling
Transcriptomics integrated with a genome-scale metabolic model identified AGC1 and PAS_chr3_0834 as effective ferulic acid tolerance targets in engineered Komagataella ...
Gene order proves as crucial as enzyme choice for rhamnosylated flavonoid yields in E. coli
Rearranging the four-gene rfb operon into a dual-promoter configuration lifted engineered E. coli to 81.9 mg/L of genistein 7-O-rhamnoside and ...
Precision Fermentation’s Next Leap Hinges on Integration, Not Single Breakthroughs
A new mini-review argues that precision fermentation will only scale when strain design, bioreactor intensification, real-time control, and techno-economic assessment ...
Deleting sugar-sensing genes turns E. coli into a sharper tumor colonizer
A genome-wide knockout screen in E. coli identified metabolic adaptations, including deletions of nonglucose phosphotransferase systems, that enhance bacterial colonization ...
Hybrid and Synthetic Vesicles Aim to Fix Extracellular Vesicle Therapy’s Biggest Flaws
A new mini-review details how hybrid and synthetic extracellular vesicle platforms are being engineered to overcome the low yield, heterogeneity, ...
Knocking out three transporters reshapes selenium metabolism in engineered Bacillus subtilis
Researchers identified three Bacillus subtilis transporters that move Se-methylselenocysteine into cells and found that deleting their genes triggers selenomethionine formation ...
Yeast Genome Decoded: MEL-Producing Pseudozyma sp. SY16 Shows Binucleate Cells
A high-quality draft genome of the MEL-producing yeast Pseudozyma sp. SY16 reveals conserved biosynthetic genes and evidence of binucleate cells.
Microbial Pigments Emerge as Next-Generation Natural Food Colorants
A new review examines how pigments from fungi, bacteria and microalgae could replace synthetic food dyes, and what obstacles remain.
Engineered E. coli biosensor tracks resveratrol production with HPLC-level accuracy
An engineered E. coli biosensor built on the Pseudomonas putida ttg operon estimated biosynthetic resveratrol concentrations with 92.7 to 93.8 ...
Engineered Microbes Move Closer to Replacing Plant Oils as the Source of a Valued Anti-Inflammatory Fatty Acid
A new review maps how engineered fungi, yeasts, and microalgae could displace plant seed oils as the dominant source of ...
Streptomyces Bacteria Emerge as Underexplored Factories for Biodegradable Plastic
A new review examines how Streptomyces bacteria could produce polyhydroxyalkanoate bioplastics, highlighting omics insights, bioprocess optimization and the barriers still ...
Precision Fermentation Moves From Fuel and Feed to the Future of Food
University of Illinois researchers say precision fermentation, long used for fuel and animal feed, could help address global food insecurity ...
New computational framework predicts whether engineered microbial traits survive evolution
A new computational framework called TRAEV predicts whether engineered metabolic traits in microbial strains will persist under adaptive evolution in ...
Self-timing gene circuit lifts microbial 3-hydroxypropionic acid yields
Researchers at Shandong University built a three-module self-induced gene circuit from quorum sensing and stationary phase signals that raised 3-hydroxypropionic ...
Boosting a Single Vitamin E Gene Raises Antioxidant Defenses in Tomato
Overexpressing the VTE3 gene in tomato increased α-tocopherol accumulation in fruit and reduced reactive oxygen species under abiotic stress, a ...
The potential of metabolic engineering for sustainable phytosterol production
A 2026 review synthesizes plant, enzyme-engineering and microbial approaches to phytosterol production, including a reported engineered-yeast campesterol titer of 5.88 ...
