PTGS1 Silencing Boosts M2 Macrophages to Ease Prostatitis
A study in the Journal of Cellular and Molecular Medicine reveals that silencing PTGS1 promotes M2 macrophage polarization via PPARĪ³ ...
Tag: Macrophage polarization
Smart Biomaterials Advance Immunomodulation and Tissue Regeneration in Periodontal Disease
A comprehensive review details how smart biomaterials responsive to endogenous biochemical signals and external physical triggers modulate immune microenvironments to ...
TMCC2 Suppresses Osteosarcoma Growth and Connects to M1 Macrophage Responses
A laboratory study shows TMCC2 suppresses osteosarcoma growth across cellular and mouse models while correlating with M1-like macrophage responses.
Piperine-Primed Stem Cell Secretome Induces Anti-Inflammatory Shift in Mouse Macrophages
In an in vitro study, conditioning rat bone marrow mesenchymal stem cells with piperine generated a secretome that promoted an ...
Injectable Microfluidic Microspheres Co-Delivering Herbal Extract and Stem Cells Improve Myocardial Infarction Repair
Researchers developed a gas-shearing microfluidic sodium alginate microsphere delivery system to co-deliver Corydalis yanhusuo ethanolic extract and mesenchymal stem cells, ...
Research report: Infection-osteogenesis crosstalk on TiO2 nanotube surfaces: mechanisms and synergistic design strategies
A review analyzes how titanium dioxide nanotube surfaces navigate infection-osteogenesis crosstalk to simultaneously combat bacterial infection and promote bone regeneration.
Synovial protein HAPLN1 drives inflammatory macrophage switch in rheumatoid arthritis study
Lab experiments show that HAPLN1 secreted by rheumatoid arthritis synovial fibroblasts pushes macrophages toward a proinflammatory M1 state through PI3K/AKT/NF-ĪŗB ...
Tiny vesicles may drive Sjƶgren’s disease and offer new diagnostic and therapeutic leads
A review outlines how extracellular vesicles contribute to Sjƶgren's disease pathology while carrying molecular signatures that could serve as non-invasive ...
Immune Cytokine MIF Keeps Macrophage Mitochondria Firing During Inflammation
New research shows that the cytokine MIF does not dictate whether macrophages become inflammatory or repair-like, but instead supplies the ...
Self-Fueling Hydrogel Heals MRSA-Infected Diabetic Wounds in Mice
Researchers have created an injectable hydrogel that uses the reactive molecules of infected diabetic wounds as fuel to kill MRSA ...
Caloric Restriction Makes Colorectal Tumors More Vulnerable to Radiation in Mice
In a mouse and cell study, caloric restriction and fasting enhanced radiation's tumor-killing effects through the cGAS-STING pathway while protecting ...
Electroacupuncture Lowers Cholesterol Through a Nuclear Receptor Pathway, Review Finds
A narrative review synthesizes preclinical and clinical evidence that electroacupuncture's lipid-lowering effects run through the PPARĪ³/LXRĪ± nuclear receptor axis, while ...
Hypoxia-Preconditioned Exosomes Speed Fistula Healing in Rat Study
In a rat model of enterocutaneous fistula, gelatin sponges loaded with hypoxia-preconditioned exosomes reduced inflammation, shifted macrophages toward a reparative ...
Immune Cells Skew Toward Inflammation in Children With Newly Diagnosed ITP
A case-control study of 32 children with newly diagnosed immune thrombocytopenia found a pro-inflammatory shift in circulating monocyte-macrophage polarization and ...
Neural Stem Cells May Rewire the Immune Response After Spinal Cord Injury
A new review argues that neural stem cells may aid spinal cord injury recovery mainly by reprogramming macrophages and other ...
Natural Products Target Mitochondria and Macrophage Crosstalk in Kidney Disease Review
A new review examines how mitochondrial dysfunction and macrophage inflammation interact in diabetic nephropathy and whether natural products can modulate ...
Green tea compound and self-assembled collagen nanospheres reverse UV skin damage in mice
Self-assembled nanospheres combining green tea EGCG and recombinant human collagen reversed UVB-induced skin photoaging in mice, outperforming either component alone.
Research report: Near-infrared light-activated collagen-based hydrogel with oriented microchannel structure promoting fibroblast infiltration and inflammatory resolutionā
A light-activated collagen hydrogel with aligned microchannels released spermidine on demand, killed more than 95 percent of test bacteria under ...
HSP90B1 drives cardiomyocyte pyroptosis and inflammation after heart attack, mouse study finds
A new study links the ER chaperone HSP90B1 to cardiomyocyte pyroptosis, NF-ĪŗB/NLRP3 signaling, and M1-like macrophage polarization after myocardial infarction.
Ancient Chinese Formula Sini Decoction Rewires Immune Cells in Lab Study of Atherosclerosis
A cell study reports that Sini Decoction-containing serum dose-dependently shifted LPS-stimulated macrophages toward an anti-inflammatory state and upregulated NCOR1, though ...
