Turmeric-Powered Nanofiber Scaffold Rewires Infected Wounds to Heal Faster
A curcumin-loaded, polydopamine-coated electroactive nanofiber scaffold killed wound bacteria, remodeled inflammation, and nearly closed infected rat wounds within two weeks.
Tag: Macrophage polarization
Reprogramming the Immune System: A New Toolbox for Healing Chronic Wounds
A new review outlines how immunomodulation and immunoengineering, from extracellular vesicles and stem cells to smart theranostic dressings, could reset ...
Fat Tissue’s Hidden Cocktail May Rewire Inflamed Immune Cells, Review Finds
A new review proposes that the secretome of freshly isolated adipose-derived Stromal Vascular Fraction can dampen NF-κB signaling and reprogram ...
Molecular Cage Supercharges Blood-Thinner Absorption and Calms Inflammation in Mice
A cucurbituril host–guest formulation of ticagrelor boosts solubility, doubles systemic exposure, and shifts macrophages toward an anti-inflammatory state in preclinical ...
Immune Cells in the Ovary May Hold the Key to Slowing Female Reproductive Aging
A new review in the Journal of Ovarian Research argues that age-related shifts in ovarian macrophages, driven by pathways such ...
Aloe vera bioink yields immune-smart 3D-printed bone organoids
Researchers have developed a Matrigel-free, aloe vera-containing bioink for 3D-printing bone organoids that recruit and polarize macrophages toward a pro-regenerative ...
Charged-Up Exosomes From Energy-Boosted Cells Heal Stubborn Diabetic Wounds
Researchers show that AICAR-activated endothelial cells release GAS6-carrying exosomes that reprogram macrophages and rebuild blood vessels, dramatically accelerating diabetic wound ...
Gut Microbe and Its Fatty Acid Break the Inflammatory Loop That Drives Obesity
A cross-species study shows that the gut bacterium Clostridium butyricum and its metabolite butyrate alleviate obesity by disrupting an LPS-EGR1 ...
Ginseng Compound Rb1 Starves Pancreatic Tumors by Turning Off Their Macrophage Allies
A ginseng-derived saponin suppresses pancreatic cancer in preclinical models by blocking the PI3K-AKT pathway and preventing macrophages from adopting a ...
Lactate Fuels a Hidden Molecular Chain That Helps Liver Cancer Evade Immunity
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
Sugar-Coated Selenium Nanoparticles Rewire Inflamed Joint Cells to Fight Osteoarthritis
Mannose-modified selenium nanoparticles target GLUT1-high inflammatory synovial cells in osteoarthritis, restoring selenoprotein antioxidant defenses, suppressing glycolysis, and easing pain and ...
Bile Acid Sensor FXR Drives Liver Regeneration by Rebuilding Its Immune Cell Army
New research shows that the bile acid receptor FXR coordinates monocyte recruitment and Kupffer cell proliferation through CCR2 and CSF1/PI3K/Akt ...
Biomaterials That Talk to the Immune System Are Reshaping Immunotherapy
A new review maps how inorganic nanoparticles, polymers, DNA nanostructures, and cell-derived vesicles are being engineered to actively reprogram the ...
Smart Hydrogel Eye Drops Fight Dry Eye by Sensing Inflammation and Sticking to the Cornea
Researchers have developed a thermosensitive, ROS-responsive, mucoadhesive hydrogel eye drop that releases the immunosuppressant mizoribine under oxidative stress and outperforms ...
Omega-3-derived lipid Resolvin E1 rejuvenates aged muscle healing by resolving inflammation
New research in GeroScience shows that the omega-3-derived lipid mediator Resolvin E1 accelerates inflammation resolution and boosts muscle stem cell ...
Common Antibiotic Calms Children’s Wheezing by Rewriting Inflammatory Memory in Lung Immune Cells
A new study shows azithromycin eases post-inflammatory wheezing in children by inhibiting SETD1B-driven H3K4me3 methylation and rebalancing macrophage polarization in ...
Chemical Tag on mRNA Emerges as Master Switch Behind Tumor Immune Evasion
A new review in the Journal of Translational Medicine details how the m6A RNA modification acts as a bidirectional switch ...
Stress Chemical NPY Revealed as Hidden Driver of Liver Scarring
New research shows that neuropeptide Y released by sympathetic nerves in the liver drives both inflammatory and profibrotic macrophage states ...
Loss of Tet2 Rewires the Aging Bone Marrow to Drive Blood Cancers, Mouse Study Shows
A new conditional knockout mouse model shows that loss of the epigenetic regulator Tet2, combined with aging and a reshaped ...
3D Bioprinted Scaffolds That Coach the Immune System to Rebuild Bone
A new review in Materials Today Bio explains how 3D bioprinting can actively orchestrate immune responses, rather than suppress them, ...
