Dormant Until They Reach the Brain: Engineered CAR-T Cells Clear a Lethal Pediatric Tumor in Mice
UC San Francisco scientists engineered B-SYNC CAR-T cells that activate only in the brain and cleared diffuse midline glioma in ...
Tag: immunotherapy
Two-pronged antibody depletes suppressive T cells and boosts antitumor immunity in mice
A new bispecific antibody targeting CCR8 and CD3 shrank breast, lung and colon tumors in mice and was well tolerated ...
CAR-NK Cells Move From Concept Toward Clinic as Review Maps Engineering Fixes
A new review synthesizes engineering strategies and early clinical findings for CAR-NK cell immunotherapy in blood cancers and solid tumors.
CAR-T Therapy for Brain Tumors Shows Early Promise and Persistent Barriers
A conference correspondence summarizing 12 clinical and translational abstracts on next-generation CAR-T therapy for malignant brain tumors, reporting early feasibility ...
Gut Microbe Butyrate Signature Flags Early Resistance to Immunotherapy in Lung Cancer
A combined gut microbiome score linking probiotic-associated bacteria and butyrate production capacity was associated with early resistance to anti-PD-1 therapy ...
Scientists Launch Global Push to Outmaneuver a Fungus That Kills More Than Half Its Victims
A new PLOS Pathogens review introduces the NIAID-funded MUCOR-ADVANCE consortium, which unites diagnostics, immunotherapy and pathogenesis research against mucormycosis, a ...
ROS-responsive nanoparticle pairs PARP inhibitor with DOT1L blocker to fire up antitumor immunity in ovarian cancer models
A ROS-responsive nanoparticle co-delivering a PARP inhibitor prodrug and a DOT1L inhibitor amplified DNA damage, activated cGAS-STING signaling and improved ...
Immunotherapy plus targeted drug shows promise in rare aggressive lung cancer
A phase 2 trial reports that camrelizumab plus famitinib produced tumor shrinkage in 42.9 percent of patients with advanced pulmonary ...
Newly identified soluble SIRPα ligand SERPINA3 dampens inflammation and shields tumors
Researchers report that SERPINA3 acts as a soluble SIRPα ligand that suppresses immune cells, easing inflammatory disease models while helping ...
AI pathology scoring flags longer survival on pembrolizumab in metastatic triple-negative breast cancer
An AI-based digital pathology assessment of PD-L1 identified metastatic triple-negative breast cancer patients with longer progression-free survival on pembrolizumab in ...
Surgery Still Dominates Early Stage Melanoma Care, but Higher-Stage Patients Face Mounting Treatment Burden
A four-site US chart review of 398 patients with stage IB–IIC melanoma found predominantly surgical management, with systemic therapy and ...
Circulating tumor cells reveal immune escape tricks that may guide immunotherapy
A new review maps how circulating tumor cells survive immune attack in the bloodstream and outlines what evidence is still ...
Natural Compounds That Build Their Own Nanomedicines Take Aim at Cancer
A new review maps how natural active compounds can self-assemble into carrier-free nanostructures for cancer therapy, while flagging major translational ...
Immune structures inside liver tumours linked to better immunotherapy outcomes
A retrospective study of 45 hepatocellular carcinoma patients found that intratumoral tertiary lymphoid structures were associated with disease control and ...
Vaccine adjuvant AS01 induces trained immunity and slows tumor growth in mice
A new study in Myeloid Cells reports that the vaccine adjuvant AS01 induces trained immunity in human monocytes and slows ...
Epigenetic drugs may restore natural killer cell power against bladder cancer
A new mini-review outlines how epigenetic silencing of NK-activating ligands helps urothelial carcinoma evade immune attack and how DNMT and ...
Six-gene T cell signature predicts survival in hepatocellular carcinoma
A six-gene T cell-derived signature built from single-cell transcriptomics stratified hepatocellular carcinoma patients by survival risk in two independent cohorts.
Bladder-Preserving Gemcitabine plus Docetaxel Shows Durable Results After Failed BCG Therapy
An updated systematic review of 12 studies in 1,248 patients finds sequential intravesical gemcitabine plus docetaxel offers durable disease control ...
Loop-mimetic vaccine targets misfolded SOD1 and slows ALS-like disease in mice
An engineered loop-mimetic antigen raised antibodies against disease-specific misfolded SOD1 and delayed disease onset in ALS-model mice.
Cholangiocarcinoma: New Advances Expose Stubborn Gaps in a Deadly Bile Duct Cancer
A new review maps the advances in diagnosing and treating cholangiocarcinoma while highlighting persistent gaps in early detection, drug resistance ...
