How Regulatory T Cells Help Ovarian Cancer Hide From the Immune System
A new review explains how regulatory T cells are co-opted by ovarian tumors to suppress immunity, and how precision therapies ...
Tag: immunotherapy
UK study maps treatment patterns and outcomes in loco-regional recurrent melanoma
A UK retrospective cohort study of 133 patients with loco-regional recurrent melanoma found surgery was the predominant treatment, with immunotherapy ...
Immune-boosted boron neutron capture therapy shows striking tumor targeting in early study
Researchers report an immune-enhanced boron neutron capture therapy platform that achieved high intratumor boron-10 levels and a model-estimated 99.6 percent ...
Lipid nanoparticles bring p53-targeted cancer therapy into focus
A new review argues that lipid nanoparticles, already clinically validated as mRNA carriers, could unify cancer therapy around restoring the ...
CD4 T Cell Help Powers Immunotherapy Response in Tumors Lacking MHC-I
Mouse experiments show that CD4+ T cells license CD8+ T cells through CD40 signaling, enabling combination immunotherapy to eliminate mismatch ...
Case Report: HER2-Low Bladder Cancer With Liver Metastases Shows Deep Remission on ADC Plus Immunotherapy
A single case report describes a 73-year-old man with HER2-low metastatic urothelial carcinoma whose liver metastases nearly resolved after treatment ...
Immunotherapy plus chemotherapy shows durable responses in lymph-node-dominant metastatic gallbladder cancer
A retrospective Chinese study reports that all 11 patients with lymph-node-dominant metastatic gallbladder cancer responded to PD-1 blockade plus gemcitabine ...
Copper-Driven Cell Death Offers a New Angle on Triple-Negative Breast Cancer
A new review outlines how the copper-dependent cell death regulator FDX1 may shape prognosis, metabolism, and treatment resistance in triple-negative ...
Marine Microbial Arginase Emerges as a Candidate for Arginine-Depriving Cancer Therapy
A new review in Medical Oncology examines marine microbial arginase as a stable enzyme platform for arginine deprivation therapy against ...
T cells in AML are not uniformly dysfunctional, researchers argue in new analysis
A BMC Medicine debate article argues that T cells in acute myeloid leukemia are not uniformly dysfunctional and that assessing ...
Massive Trial Network Crowns Cisplatin King of Head and Neck Cancer Radiotherapy Boosters
A network meta-analysis of 44 randomised trials ranks 24 radiosensitising strategies for locally advanced head and neck cancer, finding cisplatin ...
Engineered T-BET Pushes Lab-Grown NK Cells Toward Inflammation, Not Full Maturity
Forcing T-BET expression in iPSC-derived NK cells boosted IFN gamma and inflammatory chemokines but left cytotoxic function and terminal maturation ...
Hong Kong Team Makes CAR-T Therapy for Children With Leukaemia in Just 14 Days
A Hong Kong phase II trial of six children found that locally manufactured point-of-care CD19 CAR-T cells, produced in 14 ...
Rare MSH2 Variant Linked to Three Cancers in One Lynch Syndrome Patient
A Frontiers in Oncology case report documents a 62-year-old woman carrying the known pathogenic MSH2 p.A230Lfs*16 germline variant who developed ...
New framework proposes how to pick safer targets for senolytic immunotherapy
A proposed four-criteria framework for selecting senescence-associated antigens finds that neither uPAR nor GPNMB currently meets all requirements.
Lung Cancer Rewrites Its Identity: Rare Squamous Transformation Tracked by Genomic Sequencing
A case report documents an EGFR-mutant lung adenocarcinoma transforming into squamous cell carcinoma after multiple therapies, with newly detected SMAD4 ...
Extracellular vesicles emerge as dual players in tumor immunity and drug resistance
A new editorial argues that extracellular vesicles both drive tumor adaptation and drug resistance and offer promising platforms for antitumor ...
Pembrolizumab Brings Heavy Toxicity Burden for Older Breast Cancer Patients in Real-World Care
A real-world cohort study of 136 patients aged 65 and older found high rates of hospitalization and immune-related toxicity with ...
PD-L1 Levels Fail to Predict ALK Inhibitor Benefit in Lung Cancer Cohort
A 129-patient Japanese multicenter study found that tumor PD-L1 expression did not predict the effectiveness of ALK inhibitor therapy in ...
Liver Injury Affects One in Eight Patients on Immune Checkpoint Inhibitors in Real-World Study
A retrospective study of 682 patients in Tianjin found 12.17 percent developed liver injury on immune checkpoint inhibitor therapy, with ...
