BTK Inhibitor Plus Immunotherapy Shows Durable Responses in Relapsed CNS Lymphoma
A prospective phase II trial reports that orelabrutinib combined with sintilimab achieved a 60.7 percent response rate and a median ...
Tag: immunotherapy
Serine Supplements Boost T Cell Attack on Tumors in Preclinical Models
Preclinical research shows serine supplementation, rather than restriction, suppresses tumor growth and reinvigorates CD8+ T cells by countering tumor cell ...
French Bulldog Brain Tumors Show Distinct Gene Expression From Related Breeds
RNA sequencing of 18 canine brain tumors reveals 45 genes expressed at different levels in French bulldogs compared with boxers ...
Engineered IL-6-Responsive CAR Macrophages Boost CAR-T Cell Activity Against Solid Tumors
Engineered IL-6-responsive CAR macrophages enhanced CAR-T cell antitumor activity, matrix remodeling, and survival in preclinical solid tumor models.
Gene Expression Differences in Canine Brain Tumours Revealed by Breed Comparisons
An analysis of RNA from high grade oligodendroglioma tissue found 31 genes differentially expressed between French Bulldogs and closely related ...
Adding PD-1 Inhibitors to Rectal Cancer Therapy Linked to Higher Complete Response Rates
A retrospective study of 84 rectal cancer patients found that adding a PD-1 inhibitor to neoadjuvant chemoradiotherapy was associated with ...
Fibroblasts That Show Tumors’ IDs May Be Shapeshifters, Not Fixed Subtypes
A new perspective argues that antigen-presenting fibroblasts in gastrointestinal tumors are reversible states whose immune role depends on unmeasured co-stimulatory ...
Lab-Grown Tumor Organoids With Immune Cells Aim to Predict Immunotherapy Response
A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting ...
RPL22 Mutations May Shape Drug Sensitivity in Aggressive Endometrial Cancer
Researchers found RPL22 mutations in 42% of undifferentiated/dedifferentiated endometrial carcinoma samples and showed in cell and xenograft models that the ...
Gene Screens in Aged Mice Reveal Two Distinct Routes to Restore Tumor-Fighting T Cells
Genetic screens in aged mice identify Dusp5 and Zfp219 as regulators whose deletion can restore anti-tumor T cell function, with ...
Synthetic Viral RNA Shrinks NF1 Brain Tumors by Reprogramming Immune Cell Signaling
Poly(I:C), a synthetic double-stranded RNA, durably suppressed NF1-associated optic pathway glioma growth in mice by engaging TLR3 and MDA5 pathways ...
EGF-depleting vaccine plus nivolumab shows survival signal in advanced NSCLC
A phase II trial reports 11.9-month median overall survival with CIMAvax-EGF plus nivolumab in previously treated advanced NSCLC, with the ...
New Protocol Tracks Natural Killer Cells Attacking Tumors in 3D, One Cell at a Time
A newly published protocol details a three-component tumor organoid co-culture system with 3D live-cell imaging that quantifies single-cell dynamics of ...
Lipid nanoparticles emerge as leading siRNA carriers for liver cancer therapy
A new review outlines how lipid-based nanomedicines could deliver pathway-specific siRNA to treat hepatocellular carcinoma, highlighting delivery design, preclinical candidates ...
Gut Microbes Send Chemical Signals That Shape Cancer and Metabolic Disease
A new review details how microbiome-derived metabolites such as short-chain fatty acids, secondary bile acids, and tryptophan derivatives regulate host ...
Dietary restriction reshapes melanoma immune landscape and may boost immunotherapy response
A transcriptomic study links dietary restriction-associated immune and vascular changes in melanoma tumors to better prognosis and improved immunotherapy response.
AlphaFold 3 Structures Can Guide T-Cell Receptor Engineering, With Caveats
A benchmark of 438 TCR–pMHC mutations shows experimental structures remain the best input for binding-affinity predictors, while AlphaFold 3 mutant ...
Taurine-loaded nanoparticles combine photothermal therapy and immune modulation against gastric cancer in mice
Hyaluronic acid-modified taurine-polydopamine nanoparticles combined photothermal therapy with taurine-driven immune modulation to suppress gastric tumors in mice.
CD4+ Cytotoxic T Cells Emerge as Double-Edged Effectors in Health and Disease
A new review summarizes how CD4+ cytotoxic T cells act as both protective and pathological effectors, and why targeting them ...
Lactate Drives Immune Evasion in Pancreatic Cancer via TRMT6-SIRT5 Axis
A new study reports that lactate in the pancreatic tumor microenvironment promotes metabolic reprogramming and PD-L1 upregulation through the TRMT6-SIRT5 ...
