ORC1 Protein Rises with HBV Liver Disease Progression and Flags Poorer Survival
A study of 178 patients found that ORC1 expression rises from chronic hepatitis B to cirrhosis to HBV-associated liver cancer ...
Tag: Immunohistochemistry
Rare Malignant Tumor Found Growing in the Greater Omentum in 37-Year-Old Man
A case report from West China Hospital details the diagnosis, R0 surgical resection and intermediate-risk stratification of an extremely rare ...
Retrospective analysis finds uncertain HER2-low survival link in esophagogastric junction adenocarcinoma
A retrospective study of 74 resected esophagogastric junction adenocarcinomas found longer overall survival in HER2-low tumors, but HER2-low status was ...
Differential MMR protein stability and heterogeneity in bladder versus non-bladder urothelial carcinomas
In a 108-patient tissue study, mismatch repair deficiency was absent from bladder urothelial carcinoma cases and stable across paired specimens, ...
HER2 patterns vary across ovarian cancer subtypes
An analysis of 219 epithelial ovarian cancers found that HER2 protein expression and gene amplification varied by tumor subtype, while ...
Huntingtin-Associated Protein 1 Maps to Specific Hormone Cells in the Mouse Hypothalamic–Pituitary Axis
A detailed mapping study in adult male mice shows that huntingtin-associated protein 1 is distributed in a highly cell-type-specific pattern ...
Gastric protein CLDN18.2 emerges as candidate biomarker in mucinous colorectal cancer
A new review finds that the gastric tight-junction protein CLDN18.2, rare in conventional colorectal cancer, is enriched in mucinous colorectal ...
Ascites Cell Blocks Enable Ovarian Cancer Diagnosis and Molecular Profiling
A study of 58 patients found that ovarian cancer ascites-derived cell blocks supported immunohistochemical diagnosis and detected homologous recombination repair ...
Integrin α3 emerges as prognostic marker across breast cancer subtypes
A study in Cancer Pathogenesis and Therapy finds ITGA3 expression in 85.2% of breast cancer specimens and links high levels ...
HPV E6/E7 proteins linked to aggressive features in Sudanese prostate cancer
Immunohistochemical staining was positive in 48% of the 50 prostate cancer specimens and 18% of the 50 benign controls, a ...
Retrospective cohort links core biopsy to rare breast blood cancers
A retrospective 24-patient Spanish cohort found that core needle biopsy diagnosed rare hematologic breast malignancies without breast resection in 91.7% ...
Prognostic significance of folate receptor alpha expression in endometrial serous carcinoma: implications for patient stratification and targeted therapy
A retrospective study of 47 patients found that high folate receptor alpha expression was independently associated with shorter progression-free survival ...
TRPC5 staining marks heterogeneous FSGS biopsy phenotype in clinical cohort
A retrospective FSGS biopsy cohort found that heterogeneous TRPC5 staining was associated with poor treatment response and kidney failure, while ...
Rare HIV-Negative Case of Extracavitary Primary Effusion Lymphoma Diagnosed in the Stomach
A rare case of extracavitary primary effusion lymphoma has been diagnosed in an HIV-negative 61-year-old man who presented with upper ...
Rare primitive neuroectodermal tumor of the uterus diagnosed through molecular exclusion
A 46-year-old woman's uterine tumor resisted classification until two surgeries, immunohistochemistry, and next-generation sequencing excluded Ewing's sarcoma and revealed an ...
New Dataset Profiles Microsatellite Instability in Colorectal Cancers That Strike Cancer Survivors
A FAIR²-certified dataset from a single Chinese hospital documents mismatch repair and microsatellite instability status, tumor sites, histology, and comorbidities ...
Natural agents and stem cells alter healing in rat skin wounds
A controlled study of 70 male rats found that stem cells led early wound contraction, while chitosan achieved the strongest ...
Ventricular injury timelines may not fit the heart’s conduction system
A critical review finds that immunohistochemical injury timelines established in ventricular muscle cannot yet be reliably applied to the heart’s ...
A case report: an 11-year-old boy with peripheral T-cell lymphoma presenting after a five-year indolent inguinal lymphadenopathy
A case report describes an 11-year-old Ethiopian boy diagnosed with advanced-stage peripheral T-cell lymphoma after five years of stable inguinal ...
Commentary highlights diagnostic ambiguity in reported FGFR1-rearranged acute mast cell leukemia case
A 2026 commentary finds that published evidence does not definitively resolve whether a reported FGFR1-rearranged acute mast cell leukemia was ...
POPULAR NEWS
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Review Links Mitochondrial Dysfunction to Metabolic Liver Disease Progression
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CRISPR Interference Offers Reversible Gene Silencing for Pest Management, Review Reports
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Nocardia farcinica Emerged as Leading Species in Drug-Resistant Infection Study
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Seawater Elements on Enamel May Aid Drowning Time Estimates