When Psoriasis and Vitiligo Collide: A Rare Case Reveals Clashing Immune Pathways in Human Skin
A Japanese case report of co-localized psoriasis and vitiligo reveals that IL-23 blockade cleared psoriasis but not vitiligo, highlighting distinct ...
Tag: Immunohistochemistry
SPOCK1 protein emerges as a grim prognostic marker in head and neck cancers
New research links elevated SPOCK1 levels to significantly reduced overall survival in head and neck squamous cell carcinomas, suggesting aggressive ...
Basosquamous Carcinoma: A Skin Cancer That Refuses to Sit in One Box
A new review finds that basosquamous carcinoma is molecularly closer to basal cell carcinoma but behaves aggressively enough to demand ...
Two Simple Numbers May Tell Apart Harmless and Dangerous Rare Stomach Tumors
A multicenter validation study reports that lesion size and the Ki67 proliferation index can reliably distinguish indolent oxyntic gland adenomas ...
Sticky Protein MUC5AC Emerges as Powerful Tissue Marker for Pancreatic Cancer and Precursors
A meta-analysis of 55 studies shows the mucus protein MUC5AC distinguishes pancreatic cancer and precancerous lesions from healthy and benign ...
New Antibody-Drug Conjugate SCR-A008 Shows Powerful Tumor Suppression in Gastric Cancer Models
A novel CDH17-targeted antibody-drug conjugate called SCR-A008 achieved sustained tumor inhibition in gastric cancer PDX models, with a paclitaxel combination ...
AI Reveals Why Pathologists Disagree on HER2 Scoring in Breast Cancer
A Brazilian study found that an AI model's measure of HER2 staining heterogeneity within breast cancer samples predicts where pathologists ...
Beyond target expression: a modular framework to predict who benefits from antibody–drug conjugates
A Nature Reviews Clinical Oncology Review proposes a modular biomarker framework that moves ADC patient selection beyond semi-quantitative immunohistochemistry by ...
Breast Cancer Cells Recruit Immune Allies Through TNFAIP3 to Drive Metastasis
A new study shows that high TNFAIP3 expression in breast cancer cells drives CCL2/CCR2-mediated M2-like macrophage polarization and that combining ...
Immunophenotypic Markers Reveal Poor Survival in Ghanaian Children With Non-Hodgkin Lymphoma
A Ghanaian study of 38 children with non-Hodgkin lymphoma found that BCL-2 expression and tumor spread significantly predicted survival, with ...
FGFR3 Protein Overexpression Predicts Bladder Cancer Recurrence, Study Finds
A Barcelona study of 87 patients shows that FGFR3 protein overexpression independently predicts recurrence in high-grade T1 bladder cancer, while ...
Hormone-Driven Tumors Show Stronger Apelin Staining, First Study of Its Kind Finds
A first-of-its-kind immunohistochemical study reports that cortisol-producing adrenal adenomas display significantly stronger apelin staining than normal adrenal cortex, while VEGF ...
Rare Giant Lung Tumour With Suspected Liver Spread Challenges Diagnosis and Treatment
A case report describes a 57-year-old woman with a giant intrapulmonary solitary fibrous tumour exceeding 16 centimetres, complicated by suspected ...
A Simple Staining Test Predicts Early Return of Colorectal Cancer After Liver Surgery
A pattern-based p53 immunohistochemistry test identified patients with colorectal liver metastases at nearly four times the risk of early cancer ...
PET Scan Glucose Uptake Offers Clues to Immunotherapy Biomarker in Esophageal Cancer
A retrospective study of 89 patients finds that 18F-FDG PET/CT metabolic parameters, particularly SUVmax, are statistically associated with PD-L1 expression ...
Exploring Interferon Genes in Perivascular Epithelioid Lesions
In a groundbreaking study published in Scientific Reports, researchers have delved into the role of Stimulator of Interferon Genes (STING) ...
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