Tag: Immune checkpoint inhibitors

An exploratory analysis of the phase II PROMIT trial found that gut microbiome TOPOSCORE classifications failed to predict treatment outcomes ...

Spatial profiling of melanoma tumors reveals that lipid-associated macrophage neighborhoods drive immune exclusion and predict resistance to checkpoint inhibitor therapy.

Clinicians documented the rare concurrent emergence of rheumatoid arthritis and Sjögren's syndrome in a patient receiving nivolumab for recurrent gastric ...

An observational study links pre-treatment memory B-cell enrichment and heightened cellular activation to the development of immune-related adverse events in ...

A prospective multicenter cohort study evaluates whether plasma-derived extracellular vesicles can predict response to anti-PD-(L)1 therapies in patients with advanced ...

The Chinese Anti-Cancer Association has published an open access guideline standardizing diagnosis and treatment of respiratory injury caused by tumors ...

A review in the Journal of Translational Medicine examines how metabolic reprogramming enables regulatory T cells to drive immunosuppression in ...

A longitudinal immune monitoring study showed that combining tinostamustine with nivolumab was linked to preserved adaptive immune competence and antigen-specific ...

A new review argues that gut bacterial metabolites such as butyrate and indoles can be engineered as programmable drugs to ...

A new study links tumor-derived TNF-α, CCL4-high tumor-associated neutrophils, and suppressed T-cell activity to immunotherapy resistance in non-small cell lung ...

A new review finds checkpoint inhibitors are safe and effective for virologically suppressed people with HIV, while sub-Saharan Africa remains ...

A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting ...

A new review details how engineered oncolytic viruses selectively kill tumors, ignite antitumor immunity, and where clinical translation still falls ...

A new review finds that combining immune-checkpoint inhibitors with locoregional therapies improves progression-free survival in hepatocellular carcinoma, but overall survival ...

A new study reports that the RNA m5C methyltransferase NSUN2 suppresses CCL5-driven CD8+ T cell recruitment in lung adenocarcinoma through ...

Organoid and clinical single-cell data link a DHX58-positive, CD62L-positive stem-like T-cell state to immune checkpoint blockade responsiveness in gastric cancer.

A systematic review proposes a clinically actionable biomarker stratification for immunotherapy in microsatellite-stable colorectal cancer, where response rates to checkpoint ...

A multi-phase Nature Cancer study found that an agentic AI system detected immune-related adverse events in clinical notes with retrospective ...

A retrospective bicentric study of 158 metastatic melanoma patients found that CT radiomics offered no conclusive improvement over simple tumor ...

A new review examines how chemotherapeutic agents damage sperm DNA and germ cells, and what fertility preservation options exist for ...