Researchers using quantitative multiparametric magnetic resonance imaging detected widespread microstructural alterations across cortical and subcortical brain structures that track with ...
A review in BMC Biology examines how advanced sequencing and computational tools detect ultra-rare somatic mutations and investigate their causal ...
A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis.
A new study combines a computational model of CAG repeat instability with preclinical testing of an AAV-delivered microRNA that reduced ...
Restoring the peroxisomal fission protein PEX11β improved motor and cognitive deficits and mitochondrial gene expression in a toxin-induced mouse model ...
A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and ...
Moderately cold temperatures trigger a metabolic pathway in the nematode Caenorhabditis elegans that increases lifespan and supports protein homeostasis, according ...
A PLoS Biology perspective argues that the real challenge in treating neurodegenerative disease is no longer crossing the blood–brain barrier, ...
A detailed mapping study in adult male mice shows that huntingtin-associated protein 1 is distributed in a highly cell-type-specific pattern ...
A new review argues that AI-driven passive monitoring of everyday digital data, from smartphone keystrokes to home radar sensors, could ...
New research shows that curcumin reduces mutant huntingtin aggregation, restores mitochondrial function, lowers oxidative stress, modulates epigenetic marks and suppresses ...
A new Nature Communications study shows that age-driven upregulation of the translation regulator PPP1R15B, and declining levels of the microRNA ...
A Stowers Institute scientist will help lead a $28.6 million ARPA-H effort to generate billions of protein aggregation measurements and ...
A new review argues that Huntington's disease is driven by widespread disruptions of interconnected protein networks, pointing to hub proteins ...
A new review in the Journal of Translational Medicine details how lactate and protein lactylation act as a double-edged sword, ...
In groundbreaking research published in Nature Communications, a team of interdisciplinary scientists led by Markus Miettinen from the University of ...
