Tag: cuproptosis

A narrative synthesis establishes a switch-aware framework showing that post-ischemic brain cell death is coordinated across time and anatomical compartments ...

A scientific review outlines how copper-induced mitochondrial proteotoxicity could trigger innate immune sensing to counteract immunosuppressive microenvironments in glioblastoma.

A scientific review examines how iron and copper nanoparticles activate ferroptosis and cuproptosis to target therapy-resistant hepatocellular carcinoma.

Researchers developed a cuproptosis suppression score that correlates with oncogenic signaling pathways and accurately predicts immunotherapy responses in clear cell ...

A review in Pathology and Oncology Research details how cancer cells develop composite resistance to multiple regulated cell death pathways ...

A new study in Arthritis Research & Therapy identifies a regulatory link between HNRNPA1 and SLC3A2 that influences cell viability ...

Researchers have identified an eight-gene cuproptosis signature that identifies sepsis-induced acute respiratory distress syndrome while demonstrating that CDKN1A overexpression protects ...

Researchers reveal that the ubiquitin ligase MKRN1 protects colorectal cancer cells from cuproptosis by targeting the copper transporter SLC31A1 for ...

In a mouse and cell model of alcoholic cardiomyopathy, researchers found that reduced DBT gene activity promoted copper accumulation and ...

A three-component nanoparticle that consumes tumor glucose and triggers pyroptosis and cuproptosis suppressed liver cancer growth and established immune memory ...

A review in Molecular Biology Reports describes how pro-inflammatory forms of regulated cell death, including ferroptosis, pyroptosis and necroptosis, contribute ...

A new review outlines how the copper-dependent cell death regulator FDX1 may shape prognosis, metabolism, and treatment resistance in triple-negative ...

Researchers built a prognostic model from seven m6A RNA methylation-related genes correlated with cuproptosis genes in colorectal cancer and confirmed ...

An integrated machine-learning and single-cell study identifies ENTPD5 as a context-dependent candidate marker of radioresistance in hepatocellular carcinoma, with prognostic ...

A new review in Medical Oncology details how the mitochondrial transporter SLC25A39 links glutathione import, iron-sulfur cluster assembly and tumor ...

Research reveals that FDX1 downregulation in acute myeloid leukemia drives resistance to cuproptosis via the ROS/p53/ME1 axis, suggesting a new ...

A preclinical study in Molecular Cancer reports that elesclomol and neocuproine trigger mechanistically distinct, FDX1-dependent and FDX1-independent forms of copper-driven ...

A preclinical study links ceruloplasmin and STPG3-AS1 to lipoylation and cuproptosis-associated changes in castration-resistant prostate cancer cells, but it does ...

Preclinical experiments show that METTL14 stabilizes FDX1 RNA through m6A methylation, promoting cuproptosis and suppressing clear cell renal cell carcinoma ...

A new review details how excess copper induces cuproptosis, a mitochondria-dependent form of cell death that cancer cells are uniquely ...