Tag: cerebrospinal fluid

A six-year study of older adults found that higher cerebrospinal fluid levels of the neuroplasticity marker GAP-43 predicted faster cognitive ...

Blood-Based Immune Biomarkers Urgently Needed to Diagnose Bacterial Meningitis Faster

A new review argues that peripheral blood immune signatures, analyzed through multi-omics and genetic methods, could enable earlier and more ...

CSF GFAP Rises Sharply With Age, New Reference Limits Show

A cross-sectional study of 325 screened Danish biobank participants establishes age-specific upper reference limits for Simoa-measured CSF GFAP, which rise ...

Sex Steroid Excess Found in Spinal Fluid of Newly Diagnosed IIH Patients

A translational case-control study finds excess progestins and androgens in the cerebrospinal fluid of newly diagnosed IIH patients, normalizing at ...

CSF Vesicle Metabolomics Tracks Evolving Biochemical Changes After Severe Brain Injury

Untargeted metabolomics of cerebrospinal fluid small extracellular vesicles from severe TBI patients reveals distinct temporal metabolic changes at Days 1, ...

Sliding Brain-Skull Interface Boosts Biofidelity of Finite Element Head Model

Researchers rebuilt the brain-skull interface of an atlas-based finite element head model with a smooth skull and sliding contact, then ...

Neuropsychiatric Symptoms in Alzheimer’s Disease Linked to Amyloid and Heat Shock Proteins

A cross-sectional ADNI study of 713 participants links neuropsychiatric symptoms to lower CSF amyloid-β42 and identifies heat shock protein pathways ...

Choroid Plexus Ablation Eases Hydrocephalus Brain Swelling in Mice

A viral gene therapy that ablates the cerebrospinal fluid-producing choroid plexus prevented hydrocephalus-related brain swelling in mice while moderately reducing ...

Enzymatic methylation sequencing profiles rhabdoid tumors and their cfDNA

Enzymatic conversion sequencing reproduced known methylation subgroups of pediatric rhabdoid tumors and enabled copy number profiling of tissue and cerebrospinal ...

Urine and spinal fluid biomarkers show promise for detecting glioma early

A systematic review of 20 studies finds promising but preliminary biomarker evidence in urine and cerebrospinal fluid for detecting glioma.

Cerebrospinal Fluid Analysis: From Lumbar Puncture Technique to Clinical Biomarker Interpretation

A new narrative review maps how cerebrospinal fluid physiology, lumbar puncture technique, and phase-based biomarker interpretation underpin neurological diagnosis.

Rare Childhood Brain Tumor Traced Across 68 Cases in New Systematic Review

A systematic review of 68 pediatric cases of diffuse leptomeningeal glioneuronal tumor, paired with a radiologically suspected first case from ...

New study tracks amyloid-beta and blood-brain barrier leakage in CAA

A new protocol study will track longitudinal changes in cerebrospinal fluid amyloid-beta peptides and blood-brain barrier dysfunction in cerebral amyloid ...

Rapid PCR Test Detects Lymphoma Signature in Brain Tumors During Surgery

A rapid PCR system detected the PCNSL-specific MYD88 L265P mutation in tumor tissue and cerebrospinal fluid, achieving 100% specificity in ...

SOD1 Aggregates Injected into Brain Fluid Trigger ALS in Mice

Injecting two strains of misfolded human SOD1 aggregates into the cerebrospinal fluid of transgenic mice triggered prion-like aggregation and fatal ...

Fluid-Filled Cadaver Model Keeps Ventricles Realistic for Endoscopic Surgery Training

Researchers developed a continuous fluid-filled body donor model that preserves ventricular anatomy for neuroendoscopic simulation and demonstrated a feasible bimanual ...

Choroid plexus ablation in neonatal mice cuts ventricular volume in an age-dependent window

Targeted choroid plexus ablation in neonatal iDTR mice durably reduced ventricular volume within a narrow age-dependent window and improved outcomes ...

CSF Protein Signals Stay Stable Through Repeated Freeze-Thaw Cycles in High-Throughput Assay Test

A new evaluation of the Olink Explore 3072 proximity extension assay in cerebrospinal fluid finds that protein detectability and variability ...

CSF Tests for Bacterial Meningitis: What a Major Meta-Analysis Found

A meta-analysis of 27 studies and 5,673 patients quantifies how well routine CSF tests detect bacterial meningitis.

CSF APOE4 protein levels track tau pathology better than HDL measures in Alzheimer’s