Modeling shows dura lymphatics drive rapid brain waste clearance
A new computational model integrating MRI data suggests meningeal lymphatic vessels drive rapid, convective waste clearance in the human brain.
Tag: cerebrospinal fluid
Case report links eye shingles to brain inflammation
A case report describes a 65-year-old woman with herpes zoster ophthalmicus who developed orbital apex syndrome and varicella-zoster virus-associated meningitis, ...
Early Vascular Dysfunction Precedes Neuronal Loss in Alzheimer’s Mice
A study in Fluids and Barriers of the CNS finds that early cerebrovascular dysfunction in APP/PS1 mice precedes prominent neuronal ...
Study Links Rare Disease to Brain Fluid Clearance Failure
A new study identifies Skogholt’s disease as a model for primary brain fluid clearance failure, showing that choroid plexus dysfunction ...
Vagus Nerve Stimulation Selectively Diverts Brain Fluid Flow in Rat Study
An integrated MRI investigation in rats demonstrates that transcutaneous auricular vagus nerve stimulation selectively enhances cerebrospinal fluid outflow toward the ...
Case Series Identifies Key Neurological and Imaging Features in Relapsing Polychondritis
A retrospective study of 11 hospitalized patients details the varied clinical manifestations, cerebrospinal fluid markers, and cranial imaging abnormalities associated ...
Increased CSF PKR Activation in Alzheimer’s Disease Is Associated with APOE4 Genotype
A new study using SIMOA assays finds that elevated CSF phosphorylated PKR levels in Alzheimer’s disease are associated with APOE4 ...
Dynamic MRI Protocol Tracks Oxygen Movement Across Human Brain Fluid Compartments
Researchers combined dynamic gradient-echo imaging with magnetic resonance fingerprinting to track and quantify oxygen transit into human surface cerebrospinal fluid.
Sleep Breathing Issues Linked to Brain Barrier Markers
A study of 409 participants found that sleep-disordered breathing is associated with elevated cerebrospinal fluid markers of blood-brain barrier dysfunction ...
Two Rare Brain Vessel Inflammations Look Alike but Differ in Biology, Diagnosis, and Outcome
A new review compares cerebral amyloid angiopathy-related inflammation with primary angiitis of the central nervous system, showing they overlap clinically ...
Alzheimer’s Co-Pathology Alters Cognitive Profiles in Dementia With Lewy Bodies
A cross-sectional cohort study reveals that Alzheimer's disease co-pathology in dementia with Lewy bodies is linked to stage-dependent visual impairments ...
Overlapping Antibodies Linked to Fatal Autoimmune Encephalitis
A case report in BMC Neurology details a fatal instance of autoimmune encephalitis involving coexisting anti-NMDA and anti-GAD65 antibodies, highlighting ...
Alzheimer’s Biomarkers Run Lower in African American Participants, Meta-Analysis Finds
A meta-analysis of eighteen studies found that African American participants had significantly lower tau and neurodegeneration biomarker levels in cerebrospinal ...
Phosphorylation of 14-3-3γ Impairs Its Ability to Limit Alpha-Synuclein Aggregation
A new study reveals that Ser59 phosphorylation impairs the protective ability of 14-3-3γ against alpha-synuclein aggregation and reshapes its global ...
Biofluid Biomarkers Transform Alzheimer’s Diagnosis Across Spinal Fluid, Blood, and Saliva
A systematic review details how combining cerebrospinal fluid, blood, and saliva biomarkers establishes an accessible biological framework for diagnosing and ...
Rare SORL1 variants shape a typical Alzheimer’s profile, with hints of faster decline in one genetic subgroup
A study of 1,546 patients with biomarker-confirmed symptomatic Alzheimer's disease found that 35 carriers of rare high-risk SORL1 variants showed ...
CSF cytology endures as AI and telecytology reshape spinal fluid diagnostics
A comprehensive expert review concludes that manual chamber counting and microscopic examination remain the gold standards for cerebrospinal fluid cytology, ...
Alzheimer’s biomarkers track hydrocephalus phenotype but not tap test response
A retrospective study of 63 patients found that amyloid and tau biomarker groups differed in baseline cognition, psychiatric symptoms and ...
Spinal Fluid Antibody Cutoff of 1 nmol/L Separates True GAD65 Neurological Disease from Incidental Positivity
A Mayo Clinic cohort study found that a cerebrospinal fluid GAD65-antibody level of 1 nmol/L or higher distinguished true GAD65-antibody ...
Normal Spinal Fluid Results Hid a Reversible Brain Injury in a Comatose Sepsis Patient
A case report describes a woman with meningococcal septic shock whose routine cerebrospinal fluid tests appeared normal while markedly elevated ...
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