Tag: CD8+ T cells

A multi-cohort study finds that five genes upregulated in clear cell renal cell carcinoma mark the immune microenvironment rather than ...

A mouse study in The Journal of Immunology reports that hyperglycemia reprograms T cells through an IGF1-IGF1R signaling pathway to ...

Hyaluronic acid-modified taurine-polydopamine nanoparticles combined photothermal therapy with taurine-driven immune modulation to suppress gastric tumors in mice.

A new study reports that the recurrent CREBBP Y1503C mutation promotes diffuse large B-cell lymphoma growth and CD8+ T-cell dysfunction ...

A structurally complex pectic polysaccharide from Typha angustifolia pollen promoted maturation of mouse bone marrow-derived dendritic cells and enhanced antigen-specific ...

In Ugandan adults after more than a decade of suppressive ART, stronger HIV-specific CD8⁺ T-cell effector responses were associated with ...

Brief antibody-mediated depletion of CD8+ T cells in aged APP/PS1 mice left amyloid plaques unchanged but reduced dystrophic neurites and ...

A study of TCGA and Brazilian cervical cancer cohorts found that two ERAP1 haplotypes were associated with significantly worse survival ...

A new study reports that combining the multi-target kinase inhibitor cediranib with KRASG12C inhibitors overcomes resistance by sustaining ERK blockade, ...

A new review describes how tumor-derived exosomes suppress immunity while immune-cell-derived vesicles boost antitumor responses, highlighting exosome-based vaccines and biomarkers.

A new review finds that pretreatment psychological distress is consistently associated with poorer outcomes after immune checkpoint inhibitor therapy, while ...

A new study links tumor-cell RNF128 to reduced CD8-positive T-cell infiltration and poorer immune checkpoint blockade responses in bladder cancer.

A new study in Myeloid Cells reports that the vaccine adjuvant AS01 induces trained immunity in human monocytes and slows ...

Endothelial ICAM-1 becomes polarized to the tumor periphery as melanomas grow, trapping T cells at the margins, and blocking it ...

Preclinical research shows that blocking the aryl hydrocarbon receptor reshapes myeloid–T cell crosstalk and enhances anti-PD-1 responses across mouse and ...

A reanalysis of bulk RNA-sequencing data from multiple sclerosis patients finds that CD14+ monocytes show the most extensive transcriptional and ...

Mouse experiments show that CD4+ T cells license CD8+ T cells through CD40 signaling, enabling combination immunotherapy to eliminate mismatch ...

A recombinant overlapping peptide vaccine targeting HPV16 E7, combined with 4-1BB agonist antibody, eradicated established tumors in most treated mice ...

A new narrative review finds that the clinical meaning of immune infiltration in bladder cancer depends on cell localization, functional ...

A new review maps how biomaterials can exploit cholesterol metabolism in cancer while warning that most mechanistic claims remain unproven.