Tag: CD8+ T cells

An engineered non-pathogenic bacterium carrying a PD-L1 blocker and IL-15 significantly suppressed pleural tumors and fluid buildup in a mouse ...

A study in Medical Oncology reports that the E3 ubiquitin ligase RNF152 is low in clear cell renal cell carcinoma, ...

Two newly developed mouse–marmoset chimeric monoclonal antibodies enabled controlled T cell depletion in common marmosets, revealing KSHV lytic replication and ...

A mouse breast cancer study found that CD40-stimulated B cells recruited CD8+ T cells into tumors, influenced their organization and ...

A new preclinical and retrospective clinical study reports that tumor-intrinsic CXCR5 coordinates CD8-positive T cell recruitment and p38-dependent apoptotic signaling, ...

A mouse study found that removing ANKRD11 enhanced CD8+ T-cell activity against chronic hepatitis B virus infection and cancer, but ...

A single-cell spatial analysis found similar overall immune-cell abundance but different local organization of regulatory and helper T-cell populations in ...

A mouse study found that MerTK largely mediated dexamethasone-associated suppression of antiviral CD8+ T cells and increased LCMV dissemination during ...

A retrospective study of 38 patients with advanced HPV16-positive cancers linked baseline and early serum protein measurements to outcomes from ...

A new study reveals that the protein GSDMB enhances anti-PD-1 immunotherapy in bladder cancer by driving Sema7a-mediated recruitment and activation ...

New research reveals how chemokine-driven immune infiltration and inflammatory enzymes dismantle the skin's structural framework in Post-Kala-Azar Dermal Leishmaniasis, explaining ...

A retrospective study of 126 bladder cancer patients suggests that ERAS-based perioperative nursing care is associated with gentler postoperative immune ...

A new review in Frontiers in Chemical Biology maps how molecular hydrogen reprograms oncogenic signaling, epigenetics, mitochondrial stress, and antitumor ...

Chronic kidney disease silently undermines the immune system, leaving patients dangerously vulnerable to infections that healthy bodies shrug off with ...

New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a ...

A dual-photosensitizer light treatment combined with optical clearing eradicated thick pigmented melanoma in mice by triggering a potent, long-lasting anti-tumor ...

A novel intravenous STING agonist, BI 1703880, synergises with radiotherapy and checkpoint inhibitors to generate durable anti-tumour immunity in preclinical ...

A new study shows that activating the lipid sensor PPARδ in immune cells rather than cancer cells flips the metabolic ...

A multi-omics study identifies ISG15-positive CD8 T cells and a CCL2-CCR2-mediated inflammatory loop as drivers of immune checkpoint inhibitor-induced myocarditis, ...

New research reveals that tobacco carcinogens lift a GATA4-mediated brake on the mucin MUC5B, driving fatty acid metabolism and immune ...