Brain-Bone Marrow Circuit May Link Chronic Stress to Oral Cancer Progression
A study in the International Journal of Oral Science reveals that chronic stress activates a hypothalamic-pituitary-bone marrow axis, driving immunosuppressive ...
Tag: CD8+ T cells
FGL1-LAG-3 Signaling Axis Attenuates Melanoma-Induced Muscle and Fat Wasting in Mice
Intraperitoneal administration of the immune ligand FGL1 mitigates adipose and skeletal muscle wasting in melanoma-bearing mice by signaling through the ...
RFX2 Loss Promotes Immune Escape in Lung Adenocarcinoma via Hippo Signaling
Downregulation of the transcription factor RFX2 promotes immune escape and tumor progression in lung adenocarcinoma by suppressing RASSF1 and reducing ...
Depleting HLA-DMA Suppresses Glioblastoma Phenotypes and Enhances Anti-PD-1 Response
Silencing HLA-DMA curbs glioblastoma cell malignancy and remodels tumor macrophages while enhancing anti-PD-1 immunotherapy efficacy in preclinical models.
Mitochondrial Gene Signature and NT5DC3 Predict Outcomes in Nasopharyngeal Carcinoma
A new mitochondria-related gene signature and NT5DC3 analysis identify disease prognosis and immunosuppressive traits in nasopharyngeal carcinoma.
STING Agonist Cuts TNBC Tumor Recurrence and Extends Survival in Mice
Pharmaceutical STING activation reduced primary tumor recurrence and extended survival in a mouse model of metastatic triple negative breast cancer.
RNA Molecule PGM5P4-AS1 Curbs Breast Cancer Growth and T Cell Dysfunction
Researchers identified that the long non-coding RNA PGM5P4-AS1 suppresses breast cancer progression and alleviates CD8⁺ T cell dysfunction by promoting ...
ARSB Identified as Target to Suppress Colorectal Cancer Growth and Immune Evasion
A transcriptomic profiling study identified ARSB as a candidate tumor suppressor that constrains colorectal cancer progression by coordinating ERK signaling ...
DUSP4 protein keeps cancer-killing T cells active against colorectal tumours
NUS Medicine researchers found that the protein DUSP4 helps CD8+ T cells retain their cancer-killing function and that boosting its ...
Spatial immune maps link B cells and T cell neighborhoods to colorectal cancer outcomes
Colorectal cancer prognosis has long been judged mainly by tumor stage and spread, but the immune cells living inside and ...
Tumor TNF-α Drives CCL4-Producing Neutrophils Linked to Immunotherapy Resistance in Lung Cancer
A new study links tumor-derived TNF-α, CCL4-high tumor-associated neutrophils, and suppressed T-cell activity to immunotherapy resistance in non-small cell lung ...
Serine Supplements Boost T Cell Attack on Tumors in Preclinical Models
Preclinical research shows serine supplementation, rather than restriction, suppresses tumor growth and reinvigorates CD8+ T cells by countering tumor cell ...
Caloric Restriction Makes Colorectal Tumors More Vulnerable to Radiation in Mice
In a mouse and cell study, caloric restriction and fasting enhanced radiation's tumor-killing effects through the cGAS-STING pathway while protecting ...
Dendritic cells and regulatory T cells reinforce immunosuppression in pancreatic tumors
Single-cell and spatial profiling of pancreatic tumors reveals a reinforcing loop between mature dendritic cells and regulatory T cells, mediated ...
Ginseng Compound Rg3 Rewires Tumor Macrophages and Boosts Immunotherapy in Mice
A preclinical study reports that ginseng-derived ginsenoside Rg3 binds Glut1 on tumor-associated macrophages, reprograms their metabolism, and enhances anti-PD-1 therapy ...
NAT10 and USP19 jointly stabilize CDH3 to drive colorectal cancer growth and immune evasion
A new study reports that NAT10-mediated mRNA acetylation and USP19-mediated deubiquitination jointly stabilize CDH3, promoting colorectal cancer progression and immune ...
Fungal-Derived Compound DM28 Boosts Immunoradiotherapy in Lung Cancer Model
A preclinical mouse study reports that the fungal-derived compound DM28 induces SLC3A2-linked ferroptosis and increases activated T cell infiltration when ...
Isoleucine and Valine, Not Leucine, Drive T Cell Proliferation Through c-Myc
A mouse study finds that isoleucine and valine, rather than leucine, sustain c-Myc expression and proliferation in activated CD8 T ...
RNA Methylation Enzyme NSUN2 Keeps Lung Tumors Cold and Blocks Immunotherapy
A new study reports that the RNA m5C methyltransferase NSUN2 suppresses CCL5-driven CD8+ T cell recruitment in lung adenocarcinoma through ...
Synthetic Viral RNA Shrinks NF1 Brain Tumors by Reprogramming Immune Cell Signaling
Poly(I:C), a synthetic double-stranded RNA, durably suppressed NF1-associated optic pathway glioma growth in mice by engaging TLR3 and MDA5 pathways ...
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