Glutarylation of XRCC4 Enhances Breast Cancer Response to PARP Inhibitors
A new study in Cellular Oncology reveals that glutarylation of the XRCC4 protein promotes its degradation, thereby enhancing the sensitivity ...
Tag: cancer therapy
Phytomedicine Nano-Antioxidants Offer New Strategies for Targeted Redox Cancer Therapy
Researchers evaluate how plant-derived nano-antioxidants act as dynamic redox buffers to overcome the therapeutic failures of conventional antioxidant supplements in ...
Immune Checkpoint Inhibitor Toxicities Often Become Chronic, Study Finds
A retrospective study conducted at Kuopio University Hospital in Finland reveals that immune-related adverse events (irAEs) resulting from immune checkpoint ...
Telomerase Inhibition: New Cancer Therapies and Clinical Trials
A review in Biological Research details how telomerase-targeted therapies, including imetelstat and peptide vaccines, are advancing cancer treatment by disrupting ...
Review Examines Cancer Therapy Heart Risks
A new review in Cardio-Oncology examines the rising cardiovascular mortality among cancer survivors and critiques current methods for assessing cardiotoxicity ...
Two Decades of Cancer siRNA Research Reveal Shifts Toward Nanocarrier Delivery
A bibliometric analysis of more than 27,000 publications tracks the growth of cancer siRNA therapies, shifting delivery technologies, and persistent ...
RNA’s Hidden M7G Code Shapes Cancer Growth, Immune Evasion, and Treatment Resistance
A new review maps how the m7G RNA modification acts across distinct RNA compartments to drive codon-biased translation, tumor adaptation, ...
Pyroptosis and Metabolism: How Cancer Cells Rewire Cell Death for Therapy
A new review maps how metabolic reprogramming controls gasdermin-mediated pyroptosis in tumors and outlines a four-level evidence framework for precision ...
Cancer’s shape-shifting proteins may explain why drugs stop working
A new review proposes that the constantly shifting shapes of proteins, not just genetic mutations, drive rapid and reversible drug ...
Spermidine Shows a Double-Edged Role in Colorectal Cancer Growth
A new mini review describes how the polyamine spermidine can both fuel colorectal cancer growth through the MYC–ODC–eIF5A circuit and, ...
m6A RNA modification emerges as a key sculptor of the tumor microenvironment
A new open-access review describes how the m6A RNA modification acts as a key determinant in reshaping the tumor microenvironment ...
New ATG4-targeting peptide blocks autophagy and kills cancer cells in mice
A newly designed cell-penetrating peptide that inhibits the autophagy enzyme ATG4 raised reactive oxygen species and significantly reduced tumor size ...
Cationic Lipid Nanoparticles Emerge as Versatile Delivery Platforms for Cancer Therapy
A new review examines how cationic lipid-based nanoparticles carry RNA, proteins and peptides into cancer cells, and why clinical translation ...
Computational Tools Take Center Stage in Designing Nanoparticle Cancer Drug Delivery
A new review in Clinical and Experimental Medicine examines how molecular dynamics, docking, machine learning and AI platforms are being ...
Enzyme Rivalry in Tumors: How Arginine Methyltransferases Cooperate and Compete in Cancer
A new review maps how protein arginine methyltransferases both cooperate and antagonize one another in tumors, arguing that multi-target and ...
Necroptosis emerges as a decisive switch between tumor immunity and cancer growth
A new review maps five variables that determine whether necroptosis primes antitumor immunity or fuels tumor growth, positioning radiotherapy as ...
BRD4 emerges as key regulator of STING expression in cancer cells
BET inhibition suppresses STING expression at its promoter and enhancer regions, weakening the immune response triggered by PARP inhibitors.
PLK1’s Hidden Code: How Chemical Tags Orchestrate Cell Division and Cancer
A new review synthesizes how phosphorylation, ubiquitination, methylation, SUMOylation and O-GlcNAcylation form an interconnected network that controls the mitotic kinase ...
Zinc Oxide Nanoparticles Emerge as a Selective Cancer-Killing Alternative to Chemotherapy
A new review examines how zinc oxide nanoparticles kill cancer cells selectively through reactive oxygen species, zinc ion imbalance and ...
Nanoparticle Delivery Systems Aim to Unlock Resveratrol’s Anticancer Potential
A systematic review finds that nanoparticle and liposome delivery systems consistently improve resveratrol's stability and tumor uptake in preclinical models, ...
