Tag: Cancer immunotherapy

A new review examines how peptide-functionalized hydrogels and scaffolds could support CAR-NK cell therapy in solid tumors, while noting that ...

A mechanistic review evaluates how stereotactic body radiotherapy reshapes the pancreatic ductal adenocarcinoma microenvironment by simultaneously triggering localized immune activation ...

Pharmaceutical STING activation reduced primary tumor recurrence and extended survival in a mouse model of metastatic triple negative breast cancer.

An observational study links pre-treatment memory B-cell enrichment and heightened cellular activation to the development of immune-related adverse events in ...

In rodent models and patient-derived ascites samples, lipid nanoparticles degraded TREM2 and reprogrammed tumour-associated macrophages into chimeric antigen receptor cells ...

Researchers developed TCRi, a hierarchical Bayesian information-theoretic framework that infers joint distributions of T cell clonotypes and phenotypes to predict ...

A new review synthesizes how tissue-resident memory T cells act as frontline immune sentinels in tumors and could guide biomarker ...

A genome-wide CRISPR screen identified the metabolic enzyme GALE as a tumor-intrinsic checkpoint that limits Vγ9Vδ2 T cell-mediated tumor killing ...

New research shows the immune protein perforin can kill tumor cells on its own by triggering iron-dependent ferroptosis, even when ...

A new review argues that gut bacterial metabolites such as butyrate and indoles can be engineered as programmable drugs to ...

A new review details how engineered oncolytic viruses selectively kill tumors, ignite antitumor immunity, and where clinical translation still falls ...

A fully computational study reports a 344-residue multi-epitope vaccine targeting the tumor-associated protein SART3 with favorable predicted stability, TLR4 binding ...

A mouse study in The Journal of Immunology reports that hyperglycemia reprograms T cells through an IGF1-IGF1R signaling pathway to ...

A new review examines how zinc oxide nanoparticles kill cancer cells selectively through reactive oxygen species, zinc ion imbalance and ...

A bibliometric analysis of 5,967 publications maps a decade of MDSC research, identifying leading countries, institutions, authors, and emerging research ...

A CEA-coated PLLA–ZnO nanowire nano-vaccine elicited balanced Th1/Th2 immunity and reduced tumor growth by 65–70% in a prophylactic mouse model.

A new review describes how tumor-derived exosomes suppress immunity while immune-cell-derived vesicles boost antitumor responses, highlighting exosome-based vaccines and biomarkers.

New research shows that the TREX1 exonuclease suppresses anti-tumor immunity in mice by degrading short, MRE11-derived cytosolic DNA fragments that ...

A new review finds that pretreatment psychological distress is consistently associated with poorer outcomes after immune checkpoint inhibitor therapy, while ...

A narrative review argues that the acidic tumor microenvironment suppresses antitumor immunity and that targeting acidity is a preclinically supported ...